Document Detail


Electrocardiographic precordial mapping in anterior myocardial infarction. The critical period for interventions as exemplified by methylprednisolone.
MedLine Citation:
PMID:  699256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serial 72-point precordial mapping of ECG has been recorded to describe the natural history of changes in the precordial areas of ST segment elevation and the development of Q waves in 51 patients with acute uncomplicated anterior myocardial infarction. Eight patients have been studied in the same way but received 25 mg/kg of methylprednisolone sodium succinate as a single intravenous injection within 6 hours from the onset of chest pain. There was a linear relationship between the stable precordial area of Q waves at 24 hours and the rapidly changing precordial areas of ST segment elevation at 2--3 hours, 5--6 hours and 12 hours after the onset of pain in the untreated patients. When methylprednisolone was given, the treated patients developed a smaller precordial area of Q waves at 24 hours than was predicted from the precordial area of ST elevation recorded before the drug was given. This study has introduced a technique that can provide a qualitative assessment of the relationship between ECG evidence of ischemia and infarction in each patient.
Authors:
A P Selwyn; K M Fox; E Welman; A Jonathan; J P Shillingford
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  58     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1978 Nov 
Date Detail:
Created Date:  1978-12-20     Completed Date:  1978-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  892-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Drug Evaluation
Electrocardiography
Female
Heart Conduction System / physiopathology*
Humans
Male
Methylprednisolone / therapeutic use*
Middle Aged
Myocardial Infarction / drug therapy*,  physiopathology
Regression Analysis
Time Factors
Chemical
Reg. No./Substance:
83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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