| Electrocardiographic precordial mapping in anterior myocardial infarction. The critical period for interventions as exemplified by methylprednisolone. | |
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MedLine Citation:
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PMID: 699256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serial 72-point precordial mapping of ECG has been recorded to describe the natural history of changes in the precordial areas of ST segment elevation and the development of Q waves in 51 patients with acute uncomplicated anterior myocardial infarction. Eight patients have been studied in the same way but received 25 mg/kg of methylprednisolone sodium succinate as a single intravenous injection within 6 hours from the onset of chest pain. There was a linear relationship between the stable precordial area of Q waves at 24 hours and the rapidly changing precordial areas of ST segment elevation at 2--3 hours, 5--6 hours and 12 hours after the onset of pain in the untreated patients. When methylprednisolone was given, the treated patients developed a smaller precordial area of Q waves at 24 hours than was predicted from the precordial area of ST elevation recorded before the drug was given. This study has introduced a technique that can provide a qualitative assessment of the relationship between ECG evidence of ischemia and infarction in each patient. |
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Authors:
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A P Selwyn; K M Fox; E Welman; A Jonathan; J P Shillingford |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation Volume: 58 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1978 Nov |
Date Detail:
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Created Date: 1978-12-20 Completed Date: 1978-12-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 892-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Drug Evaluation Electrocardiography Female Heart Conduction System / physiopathology* Humans Male Methylprednisolone / therapeutic use* Middle Aged Myocardial Infarction / drug therapy*, physiopathology Regression Analysis Time Factors |
| Chemical | |
Reg. No./Substance:
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83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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