Document Detail

Electrocardiographic markers for the early detection of cardiac disease in patients with beta-thalassemia major.
MedLine Citation:
PMID:  20361126     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To comparatively evaluate P-wave dispersion (PWD) in patients with beta-thalassemia major (TM) and healthy control subjects for the early prediction of arrhythmia risk. METHODS: Eighty-one children with beta-TM, aged 4-19 years, and 74 healthy children (control group) underwent routine electrocardiography and transthoracic echocardiography for cardiac evaluation. PWD was calculated as the difference between the maximum and the minimum P-wave duration. RESULTS: There was a statistically significant difference between study and control groups in peak early (E) mitral inflow velocity and E/late (A) velocity ratio. Maximum P-wave duration and PWD were found to be significantly higher in beta-TM patients than in control subjects. CONCLUSIONS: Increased PWD in our beta-TM patients might be related to depression of intra-atrial conduction due to atrial dilatation and increased sympathetic activity. These patients should be closely followed up for risk of life-threatening arrhythmias.
Kemal Nisli; Yavuz Taner; Oner Naci; Salcioglu Zafer; Karakas Zeynep; Dindar Aygun; Aydogan Umrah; Eker Rukiye; Ertugrul Turkan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Jornal de pediatria     Volume:  86     ISSN:  1678-4782     ISO Abbreviation:  J Pediatr (Rio J)     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-04-02     Completed Date:  2010-10-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985188R     Medline TA:  J Pediatr (Rio J)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  159-62     Citation Subset:  IM    
Department of Pediatric Cardiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
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MeSH Terms
Arrhythmias, Cardiac / physiopathology*,  ultrasonography
Blood Flow Velocity / physiology
Case-Control Studies
Child, Preschool
Early Diagnosis
Electrocardiogram Pattern
Risk Factors
Young Adult
beta-Thalassemia / complications*,  physiopathology

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