| Electrocardiographic markers for the early detection of cardiac disease in patients with beta-thalassemia major. | |
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MedLine Citation:
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PMID: 20361126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To comparatively evaluate P-wave dispersion (PWD) in patients with beta-thalassemia major (TM) and healthy control subjects for the early prediction of arrhythmia risk. METHODS: Eighty-one children with beta-TM, aged 4-19 years, and 74 healthy children (control group) underwent routine electrocardiography and transthoracic echocardiography for cardiac evaluation. PWD was calculated as the difference between the maximum and the minimum P-wave duration. RESULTS: There was a statistically significant difference between study and control groups in peak early (E) mitral inflow velocity and E/late (A) velocity ratio. Maximum P-wave duration and PWD were found to be significantly higher in beta-TM patients than in control subjects. CONCLUSIONS: Increased PWD in our beta-TM patients might be related to depression of intra-atrial conduction due to atrial dilatation and increased sympathetic activity. These patients should be closely followed up for risk of life-threatening arrhythmias. |
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Authors:
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Kemal Nisli; Yavuz Taner; Oner Naci; Salcioglu Zafer; Karakas Zeynep; Dindar Aygun; Aydogan Umrah; Eker Rukiye; Ertugrul Turkan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Jornal de pediatria Volume: 86 ISSN: 1678-4782 ISO Abbreviation: J Pediatr (Rio J) Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-04-02 Completed Date: 2010-10-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985188R Medline TA: J Pediatr (Rio J) Country: Brazil |
Other Details:
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Languages: eng Pagination: 159-62 Citation Subset: IM |
Affiliation:
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Department of Pediatric Cardiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. kemalnisli@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Arrhythmias, Cardiac / physiopathology*, ultrasonography Blood Flow Velocity / physiology Case-Control Studies Child Child, Preschool Early Diagnosis Echocardiography Electrocardiogram Pattern Female Humans Male Risk Factors Young Adult beta-Thalassemia / complications*, physiopathology |
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