Document Detail

Electrocardiographic left ventricular hypertrophy and arterial stiffness: the Ohasama study.
MedLine Citation:
PMID:  17161763     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Whether arterial stiffness per se contributes to left ventricular hypertrophy (LVH) independently of blood pressure (BP) remains unknown. We examined the relationship between pulse wave velocity (PWV) and LVH in a large population. METHODS: The PWV was measured between the brachial and ankle regions (baPWV) of 798 individuals. We diagnosed LVH using electrocardiographic criteria: Cornell voltage-duration product >2440 mm x msec or Sokolow-Lyon voltage >38 mm. The participants were initially separated into those with and without LVH [LVH(+) and LVH(-) groups, respectively]. To determine theoretical baPWV, we first constructed a nomogram for the LVH(-) group, calculated the PWV index (measured baPWV - theoretical baPWV) for each individual and then compared the two groups. We also examined the factors associated with LVH(+) using multivariate analyses. RESULTS: Linear regression analysis revealed that the theoretical baPWV (m/sec) = 0.20 x age (years) + 0.13 x Mean arterial pressure (MAP) (mm Hg) + 0.05 x Heart rate (beats/min) - 11.74 (R(2) = 0.56). The PWV index was greater in the LVH(+) than in the LVH(-) group (P = .025). The baPWV was independently related to LVH(+) along with MAP, medication for hypertension, and for diabetes; a 1 SD (4.3 m/sec) increase in baPWV was associated with a 26% increase in the risk of LVH(+) (P = .022). When LVH(+) risk factors were defined as hypertension, diabetes, and high baPWV (> or =14.6 m/sec), the prevalence of LVH(+) linearly increased with the number of concomitant LVH(+) risk factors (P < .001). CONCLUSIONS: Arterial stiffness is independently related to electrocardiographically determined LVH in the general population.
Daisuke Watabe; Junichiro Hashimoto; Rieko Hatanaka; Tomohiro Hanazawa; Hiromi Ohba; Takayoshi Ohkubo; Masahiro Kikuya; Kazuhito Totsune; Yutaka Imai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  19     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-02-23     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1199-205     Citation Subset:  IM    
Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Science and Medicine, Aoba, Aramaki, Sendai, Japan.
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MeSH Terms
Age Distribution
Age Factors
Aged, 80 and over
Ankle / blood supply*
Blood Flow Velocity
Blood Pressure
Brachial Artery / physiopathology*
Cross-Sectional Studies
Diabetes Complications / physiopathology
Heart Rate
Hypertension / complications,  physiopathology
Hypertrophy, Left Ventricular / epidemiology,  etiology*,  physiopathology*
Japan / epidemiology
Linear Models
Logistic Models
Middle Aged
Models, Cardiovascular
Odds Ratio
Pulsatile Flow
ROC Curve
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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