| Electrocardiographic criteria for vagotonia-validation with pharmacological parasympathetic blockade in healthy subjects. | |
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MedLine Citation:
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PMID: 12559544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The importance of vagal tone on cardiac function and cardiovascular mortality is well established. Although the presence of an enhanced cardiac vagal tone (CVT) is frequently diagnosed using the 12-lead resting electrocardiogram (ECG) in daily practice, most of the proposed criteria have been determined on an empirical basis. Our objective was to evaluate the effects of pharmacological blockade of the parasympathetic component of the autonomic nervous system on resting ECG tracings. METHODS: Nine healthy young adults (24+/-5 year-old) underwent parasympathetic blockade with atropine sulfate i.v. (0.04 mg kg(-1)) and resting ECGs were obtained before and 15 min thereafter. CVT was assessed by a dimensionless index, which measures the RR interval reduction caused by the vagal withdrawal induced by a 4-s exercise test performed on a cycle ergometer where the subjects pedal as fast as possible with no added resistance. RESULTS: This index was 1.63+/-0.24 and 1.03+/-0.03, before and after atropine, respectively (P<0.0001). Atropine reduced the R-R intervals (P<0.0001), and the amplitude of T-waves in several leads (DII: P=0.03; V4: P=0.04; V5: P=0.03; V6: P=0.01), and abolished the appiculation of T-waves, J-point and ST-segment elevations (P<0.05), and U-waves (P<0.05), which were present in baseline ECG in all subjects in at least two leads. The R-wave amplitude in leads V4, V5, and V6 (all P>/=0.10) was not modified by atropine infusion. CONCLUSION: The duration of the R-R intervals and the amplitude of T-waves in leads DII, V4, V5, and V6, and the presence of T-wave appiculation, U-waves, and elevation of J-point and ST-segment should be used to detect enhanced cardiac vagal tone in healthy subjects. |
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Authors:
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José Kawazoe Lazzoli; Pedro Paulo da Silva Soares; Antonio Claudio Lucas da Nóbrega; Claudio Gil Soares de Araújo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
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Title: International journal of cardiology Volume: 87 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-01-31 Completed Date: 2003-05-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 231-6 Citation Subset: IM |
Affiliation:
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Department of Morphology, Universidade Federal Fluminense, Niterói, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atropine / pharmacology* Electrocardiography* Female Humans Male Parasympathectomy / methods* Parasympathetic Nervous System / drug effects*, physiology Probability Prospective Studies Reference Values Sensitivity and Specificity Vagus Nerve / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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