Document Detail

Electrocardiographic criteria for detecting coronary artery disease in hypertensive patients with ST-segment changes during exercise testing.
MedLine Citation:
PMID:  19176227     Owner:  NLM     Status:  MEDLINE    
PURPOSE: It is well known that patients with arterial hypertension frequently present with ischemic electrocardiographic changes during exercise testing without actually having coronary artery disease (CAD). The purpose of this study was to establish additional electrocardiographic criteria during exercise testing for detecting CAD in hypertensive patients with ischemic ST-segment response. METHODS: Three hundred eighty-two consecutive hypertensive patients (224 males, 58 +/- 8 years) who presented with ischemic electrocardiographic changes during exercise testing and agreed to undergo coronary arteriography were included in the study. RESULTS: From 382 hypertensive patients undergoing coronary angiography, only 76 (20%) had significant coronary stenosis, whereas 306 (80%) had normal coronary arteries. From 382 patients, 287 (75%) (group A) presented with ST-segment depression during exercise in leads II-III-aVF-V(6), 271 (94%) of which had normal arteries at the angiography. The remaining 95 patients (25%) (group B) of the studied patients presented with ST-segment depression in II-III-aVF and/or V(4) through V(6), 60 (63%) of which had CAD. Furthermore, 251 patients of group A presented with ST-segment depression during the fourth to sixth minute of the recovery period in V(4) through V(6), 247 (98%) of which had normal arteries. Another 28 patients from group B presented with ST-segment depression during the fourth to eighth minute of the recovery period in V(4) through V(6), 22 (79%) of which had significant coronary artery stenosis. CONCLUSIONS: Hypertensive patients who present with ST-segment depression during exercise in leads II-III-aVF and/or V(4) through V(6) and with a prolonged duration of this depression at the recovery phase (fourth to eighth minute) are more likely to have CAD. Absence of ST-segment depression in V(4) and V(5) at the end of exercise or during the seventh and eighth minute of recovery favors a false-positive result.
Andreas P Michaelides; Charalampos I Liakos; Leonidas G Raftopoulos; Charalambos Antoniades; Gregory Vyssoulis; George Andrikopoulos; Nikolaos Ioakeimides; Constantinos Tsioufis; Dimitrios Soulis; Christodoulos Stefanadis
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-01-26
Journal Detail:
Title:  Journal of electrocardiology     Volume:  42     ISSN:  1532-8430     ISO Abbreviation:  -     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2009-08-21     Completed Date:  2009-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  405-9     Citation Subset:  IM    
1st University Department of Cardiology, Exercise Laboratory, Athens Medical School, Hippokration Hospital, Athens, Greece.
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MeSH Terms
Coronary Stenosis / complications*,  diagnosis*
Electrocardiography / methods*
Exercise Test
Hypertension / complications*,  diagnosis*
Middle Aged
Reproducibility of Results
Sensitivity and Specificity

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