Document Detail

Electrocardiographic changes at the onset of epileptic seizures.
MedLine Citation:
PMID:  12614390     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We studied heart-rate (HR) changes at the transition from the preictal to the ictal state in patients with focal epilepsies to gain some insight into the mechanisms involved in the neuronal regulation of cardiovascular function. METHODS: We assessed ECG changes during 145 seizures recorded with scalp EEG in 58 patients who underwent video-EEG monitoring. Consecutive RR intervals were analyzed with a newly developed mathematical method for a total of 90 s. RESULTS: Ictal-onset tachycardia occurred in 86.9% of all seizures, whereas bradycardia was documented only in 1.4%. The incidence as well as the amount of ictal HR increase was significantly more pronounced in patients with mesial temporal lobe epilepsy (TLE) as compared with those with non-lesional TLE or extratemporal epilepsy. Moreover, right hemispheric seizures were associated with ictal-onset tachycardia. On average, ictal HR increase preceded EEG seizure onset by 13.7 s in TLE patients and 8.2 s in patients with extratemporal epilepsy. This difference was significant. Ictal HR changes could be classified according to their temporal evolution into two different patterns. These two patterns differed significantly between the temporal lobe and the extratemporal epilepsy patient group. CONCLUSIONS: Epileptic discharges directly influence areas of the central autonomic network, thus regulating HR and rhythm. Such changes occur before ictal discharges appear on surface electrodes. Our newly developed method may be of potential use for clinical applications such as automatic seizure-detection systems. Moreover, our method might help to clarify further the basic mechanisms of interactions between heart and brain.
Fritz Leutmezer; Christiana Schernthaner; Stefanie Lurger; Klaus Pötzelberger; Christoph Baumgartner
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epilepsia     Volume:  44     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-04     Completed Date:  2003-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  348-54     Citation Subset:  IM    
Neurologische Universitätsklinik Wien, Vienna, Austria.
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MeSH Terms
Autonomic Nervous System / physiopathology*
Bradycardia / diagnosis*,  physiopathology
Brain / physiopathology
Diagnosis, Differential
Electrocardiography / methods,  statistics & numerical data*
Electroencephalography / statistics & numerical data
Epilepsies, Partial / diagnosis,  physiopathology*
Epilepsy, Temporal Lobe / diagnosis,  physiopathology
Functional Laterality / physiology
Heart / innervation*
Heart Rate / physiology
Models, Cardiovascular
Models, Neurological
Neural Pathways / physiopathology
Retrospective Studies
Tachycardia / diagnosis*,  physiopathology
Videotape Recording

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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