| Electrocardiographic abnormalities in patients bitten by taipans (Oxyuranus scutellatus canni) and other elapid snakes in Papua New Guinea. | |
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MedLine Citation:
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PMID: 9093629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Envenoming by a number of species of snake may affect the myocardium or cause electrocardiographic changes; several different mechanisms have been proposed. In a prospective study of snake bite in Papua New Guinea, electrocardiographic changes were observed in 36 of 69 patients (52%) envenomed by the taipan (Oxyuranus scutellatus), 2 of 6 (33%) envenomed by death adders (Acanthophis sp.) and one envenomed by the brown snake (Pseudonaja textilis). Septal T wave inversion and bradycardias, including atrioventricular block, were the commonest abnormalities. There was no haemodynamic deterioration. The cause of these changes is uncertain; only 2 of 24 patients (8.3%) with electrocardiographic changes had markedly elevated plasma concentrations of cardiac troponin T, a sensitive and specific marker of myocardial damage. This suggests that myocardial damage is uncommon following bites by these species. Electrocardiographic abnormalities are most likely to have been caused by a direct toxic effect of a venom component upon cardiac myocyte function; in taipan bites, taicatoxin, a calcium channel blocker, might be responsible. |
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Authors:
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D G Lalloo; A J Trevett; N Nwokolo; I F Laurenson; S Naraqi; I Kevau; M W Kemp; R James; L Hooper; R David; G Theakston; D Warrell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transactions of the Royal Society of Tropical Medicine and Hygiene Volume: 91 ISSN: 0035-9203 ISO Abbreviation: Trans. R. Soc. Trop. Med. Hyg. Publication Date: 1997 Jan-Feb |
Date Detail:
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Created Date: 1997-04-17 Completed Date: 1997-04-17 Revised Date: 2009-09-29 |
Medline Journal Info:
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Nlm Unique ID: 7506129 Medline TA: Trans R Soc Trop Med Hyg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 53-6 Citation Subset: IM |
Affiliation:
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Centre for Tropical Medicine, John Radcliffe Hospital, Oxford, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Coagulation Disorders / physiopathology Bradycardia / physiopathology Cardiomyopathies / blood, etiology, physiopathology* Creatine Kinase / blood Elapid Venoms / poisoning* Elapidae* Electrocardiography Hemodynamics Humans Myocardium / metabolism Papua New Guinea Prospective Studies Snake Bites / blood, complications, physiopathology* Troponin / blood Troponin T |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Elapid Venoms; 0/Troponin; 0/Troponin T; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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