| Electrocardiographic abnormalities in hypothyroidism before and after exercise. | |
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MedLine Citation:
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PMID: 913359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eleven men and 50 women with severe hypothyroidism were studied. All patients had a serum PBI less than 3.0 mug/100 ml, 131I 24 hours uptake less than 13% and a a photomotogram contraction and half relaxation time of 380 msec or more. Before exercise the mean +/- SE heart rate was 68.39 +/- 3.26/min, the PR interval 17.08 +/- 0.37 csec, the QRS voltage (sum of the QRS amplitude in leads I, II and III) 16.44 +/- 0.89 mm (10mm = 1.0 mV) and the T wave amplitude 0.06 +/- 0.15 mm. A significant correlation (p less than 0.05) existed between the PBI values and the QRS voltage. Following exercise there was a significant acceleration of the heart rate (+ 23.39/min, p less than 0.001), shortening of the PR interval (-0.66 csec, p less than 0.02) and T wave elevation (+ 0.40 mm, p less than 0.001). ST segment changes were not observed in any case. Replacement treatment in 7 cases resulted in a significant change in the resting heart rate (+ 11.86/min. p less than 0.025), PR interval (-3.28 mm, p less than 0.025) and T wave height (+ 2.50 mm, p less than 0.01). These findings suggest that exercise may be used in the differentiation between hypothyroidism and coronary heart disease. The theoretical importance of these findings is also discussed. An increase in cardiac energy demands during exercise may be the cause for some of the ECG changes observed on exertion. |
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Authors:
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D G Boufas; D A Koutras; D A Sideris; A Koukoulommati-Spentza; S D Moulopoulos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endokrinologie Volume: 69 ISSN: 0013-7251 ISO Abbreviation: Endokrinologie Publication Date: 1977 |
Date Detail:
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Created Date: 1977-12-29 Completed Date: 1977-12-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370675 Medline TA: Endokrinologie Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: 341-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Electrocardiography Female Heart / physiology* Heart Rate Humans Hypothyroidism / drug therapy, physiopathology* Male Middle Aged Physical Exertion* Thyroxine / therapeutic use |
| Chemical | |
Reg. No./Substance:
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7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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