Document Detail


Electrocardiographic QT interval and mortality: a meta-analysis.
MedLine Citation:
PMID:  21709561     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Extremely abnormal prolongation of the electrocardiographic QT interval is associated with malignant ventricular arrhythmias and sudden cardiac death. However, the implications of variations in QT-interval length within normal limits for mortality in the general population are still unclear.
METHODS: We performed a meta-analysis to investigate the relation of QT interval with mortality endpoints. Inverse-variance weighted random-effects models were used to summarize the relative risks across studies. Twenty-three observational studies were included.
RESULTS: The pooled relative risk estimates comparing the highest with the lowest categories of QT-interval length were 1.35 (95% confidence interval = 1.24-1.46) for total mortality, 1.51 (1.29-1.78) for cardiovascular mortality, 1.71 (1.36-2.15) for coronary heart disease mortality, and 1.44 (1.01-2.04) for sudden cardiac death. A 50 milliseconds increase in QT interval was associated with a relative risk of 1.20 (1.15-1.26) for total mortality, 1.29 (1.15-1.46) for cardiovascular mortality, 1.49 (1.25-1.76) for coronary heart disease mortality, and 1.24 (0.97-1.60) for sudden cardiac death.
CONCLUSIONS: We found consistent associations between prolonged QT interval and increased risk of total, cardiovascular, coronary, and sudden cardiac death. QT-interval length is a determinant of mortality in the general population.
Authors:
Yiyi Zhang; Wendy S Post; Elena Blasco-Colmenares; Darshan Dalal; Gordon F Tomaselli; Eliseo Guallar
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  22     ISSN:  1531-5487     ISO Abbreviation:  Epidemiology     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-03     Completed Date:  2012-03-07     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  660-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Arrhythmias, Cardiac / diagnosis*,  mortality*
Cardiovascular Diseases / mortality
Coronary Disease / mortality
Death, Sudden, Cardiac / epidemiology
Electrocardiography*
Humans
Risk
Grant Support
ID/Acronym/Agency:
ES015597/ES/NIEHS NIH HHS; HL091062/HL/NHLBI NIH HHS; R01 ES015597/ES/NIEHS NIH HHS; R01 ES015597-01A2/ES/NIEHS NIH HHS; R01 ES015597-02/ES/NIEHS NIH HHS; R01 ES015597-03/ES/NIEHS NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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