Document Detail


Electrocardiogram, hemodynamics, and core body temperatures of the normal freely moving laboratory beagle dog by remote radiotelemetry.
MedLine Citation:
PMID:  16380274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The objectives of this study were to provide baseline normative values for circadian changes in the time-series data collected over the course of a normal day in laboratory-housed dogs and to assess the relative efficiency of standard correction formulas to correct for the variations in QT intervals and heart rate functions. METHODS: One hundred and twenty-three beagle dogs (65 M, 58 F) were equipped with radiotelemetry transmitters and continuously monitored, while freely moving in their home cages. Electrocardiograms (ECGs), hemodynamic parameters (diastolic, systolic, and mean arterial pressures) as well as core body temperatures were recorded for 22 h. RESULTS AND DISCUSSION: Blood pressures and core body temperatures demonstrated only very slight variations in their respective values over the 22-h monitoring period. ECGs were measured by a computerized waveform analysis program and quantitative elements reported as RR, PR, QRS, and QT intervals. Little circadian rhythmicity was demonstrated in the ECG intervals. Standard study-specific correction formulas appeared to satisfactorily normalize (i.e., compensate for) the relationship between heart rate and QT intervals in these beagle dogs but elevated the values of the QTc as compared to the uncorrected QT intervals. In sharp contrast, a subject-specific correction method based on analysis of covariance produced a more linear function between heart rates and QT intervals and, more importantly, provided QTc values within the normal range of actual, recorded QT interval data.
Authors:
David V Gauvin; Larry P Tilley; Francis W K Smith; Theodore J Baird
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-27
Journal Detail:
Title:  Journal of pharmacological and toxicological methods     Volume:  53     ISSN:  1056-8719     ISO Abbreviation:  J Pharmacol Toxicol Methods     Publication Date:    2006 Mar-Apr
Date Detail:
Created Date:  2006-03-01     Completed Date:  2006-07-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9206091     Medline TA:  J Pharmacol Toxicol Methods     Country:  United States    
Other Details:
Languages:  eng     Pagination:  128-39     Citation Subset:  IM    
Affiliation:
Safety Pharmacology MPI Research, Inc., 54943 North Main St., Mattawan, MI 49071-9399, USA. david.gauvin@mpiresearch.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Temperature / physiology*
Dogs / physiology*
Electrocardiography / instrumentation*,  methods
Female
Hemodynamics / physiology*
Male
Reference Values
Telemetry / instrumentation*,  methods
Thermography / instrumentation*,  methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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