| Electroanalysis and simultaneous determination of 6-thioguanine in the presence of uric Acid and folic Acid using a modified carbon nanotube paste electrode. | |
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MedLine Citation:
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PMID: 21985923 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The present work describes the preparation and characterization of a carbon nanotube paste electrode modified with 2,7-bis(ferrocenyl ethyl)fluoren-9-one (2,7-BF). This electrode showed an efficient catalytic activity for the electro-oxidation of 6-thioguanine (6-TG), which leads to lowering 6-TG overpotential by more than 610 mV. Also, the values of catalytic rate constant (k = 2.7 × 10(3) mol(-1) L s(-1)), and diffusion coefficient (D = 2.7 × 10(-5) cm(2) s) were calculated. In 0.1 M phosphate buffer solution of pH 7.0, the oxidation current increased linearly with two concentration intervals of 6-TG, one is 0.06 to 10.0 µmol L(-1) and the other is 10.0 to 160.0 µmol L(-1). The detection limit (3σ) obtained by differential pulse voltammetry (DPV) was 22.0 nmol L(-1). DPV was used for simultaneous determination of 6-TG, uric acid (UA) and folic acid (FA) at the modified electrode, and for quantification of 6-TG, UA and FA in some real samples by the standard addition method. |
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Authors:
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Hadi Beitollahi; Jahan-Bakhsh Raoof; Rahman Hosseinzadeh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry Volume: 27 ISSN: 1348-2246 ISO Abbreviation: Anal Sci Publication Date: 2011 |
Date Detail:
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Created Date: 2011-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511078 Medline TA: Anal Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 991 Citation Subset: IM |
Affiliation:
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Environment Department, Research Institute of Environmental Sciences, International Center for Science, High Technology and Environmental Sciences. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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