| Electroacupuncture reversed the inhibition of intestinal peristalsis induced by intrathecal injection of morphine in rabbits. | |
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MedLine Citation:
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PMID: 8325148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Morphine elicits a series of adverse effects including the inhibition of intestinal motility in addition to the therapeutic benefit of alleviating postoperative pain. To ascertain the role of electroacupuncture (EA) in diminishing those detrimental effects on recovery, we imitated the clinical procedures in rabbits. Morphine was given via a preimplanted cannula within spinal subarachnoid space, while the duodenal motility, respiration rate and arterial pressure were simultaneously recorded. It was found that morphine (6 mg/rabbit, IT) markedly suppressed duodenal peristalsis, decreased respiration rate throughout 90 min observation. When EA was administered together with morphine, peristalsis of the duodenum was much less inhibited (P < 0.05, vs morphine alone group), but no significant improvement of respiratory depression was noticed (P > 0.05), nor obvious change of arterial pressure in both groups. The results strongly recommend extensive application of EA in postoperative care, so as to decrease both the required dosage of morphine and the subsequent occurrence of postoperative ileus, while attaining sufficient analgesia. |
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Authors:
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J L Dai; Z J Ren; Z M Fu; Y H Zhu; S F Xu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chinese medical journal Volume: 106 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-08-06 Completed Date: 1993-08-06 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: CHINA |
Other Details:
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Languages: eng Pagination: 220-4 Citation Subset: IM |
Affiliation:
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Department of Neurobiology, Shanghai Medical University. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Duodenum / physiology Electroacupuncture* Female Injections, Spinal Intestine, Small / drug effects, physiology* Male Morphine / pharmacology* Peristalsis / drug effects Rabbits |
| Chemical | |
Reg. No./Substance:
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57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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