| Electroacupuncture inhibits inflammation reaction by upregulating vasoactive intestinal Peptide in rats with adjuvant-induced arthritis. | |
| | |
MedLine Citation:
|
PMID: 20953422 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Acupuncture is emerging as an alternative therapy for rheumatoid arthritis (RA). However, the molecular mechanism underlying this beneficial effect of acupuncture has not been fully understood. Here, we demonstrated that electroacupuncture at acupoints Zusanli (ST36), Xuanzhong (GB39); and Shenshu (BL23) markedly decreased the paw swelling and the histologic scores of inflammation in the synovial tissue, and reduced the body weight loss in an adjuvant-induced arthritis rat model. However, the electrical stimulation at nonacupoint did not produce any beneficial effects against the experimental arthritis. Most interestingly, the electroacupuncture treatment resulted in an enhanced immunostaining for vasoactive intestinal peptide (VIP), a potent anti-inflammatory neuropeptide, in the synovial tissue. Moreover, the VIP-immunostaining intensity was significantly negatively correlated with the scores of inflammation in the synovial tissue (r = -0.483, P = .0026). In conclusion, these findings suggest that electroacupuncture may offer therapeutic benefits for the treatment of RA, at least partially through the induction of VIP expression. |
| | |
Authors:
|
Tian-Feng He; Wen-Jia Yang; Shu-Hui Zhang; Chun-Yan Zhang; Lian-Bo Li; Yun-Fei Chen |
Publication Detail:
|
Type: Journal Article Date: 2010-09-14 |
Journal Detail:
|
Title: Evidence-based complementary and alternative medicine : eCAM Volume: 2011 ISSN: 1741-4288 ISO Abbreviation: Evid Based Complement Alternat Med Publication Date: 2011 |
Date Detail:
|
Created Date: 2010-10-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101215021 Medline TA: Evid Based Complement Alternat Med Country: England |
Other Details:
|
Languages: eng Pagination: - Citation Subset: - |
Affiliation:
|
Institute of Acupuncture-Moxibustion and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The basic cardiovascular responses to postural changes, exercise, and cold pressor test: do they var...
Next Document: In Vivo Effects of Cagaita (Eugenia dysenterica, DC.) Leaf Extracts on Diarrhea Treatment.