Document Detail

Electro-acupuncture of Tsusanli and Shangchuhsu regulates gastric activity possibly through mediation of the vagus-solotary complex.
MedLine Citation:
PMID:  18019736     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Acupuncture has been reportedly used to treat gastrointestinal diseases, however, its precise mechanism remains unknown. METHODOLOGY: In our study, the effects and mechanism of electro-acupuncture (EA) at Tsusanli (ST 36), Shangchuhsu (ST 37) on regulation of gastric activity were observed. RESULTS: EA at Tsusanli showed that gastric electric change was the most obvious, with significantly higher frequency and wave amplitude compared with that of the Shangchuhsu group and other groups. EA at Shangchuhsu demonstrated that the change of gastric electric level was much higher than that of the non-acupoint group and control group. After bilateral vagotomy, Tsusanlis was electro-acupunctured, the changes of electro-gastric graph (EGG) weren't significant with the control group. The frequency of electro-physiological activity in nucleus of solitary tract (NTS) and dorsal motor nucleus of the vagus nerve (DMV) in the Tsusanli group was markedly increased compared with that in the other group. Fos and GFAP expression in NTS and DMV in the Tsusanli group was significantly higher than that in other groups and control group. The results have indicated that EA at Tsusanli and Shangchuhsu cannot only regulate gastric activity, but also activate neurons and astrocytes in NTS and DMV. The effects on regulation and activation of EA at Tsusanli were very obvious. CONCLUSIONS: Our study suggests that this electroacupuncture regulation of gastric activity may partially depend upon integrated nerve pathway and related central neurons and astrocytes in the vagus-solitary complex.
Jing-Jie Wang; Xiao-Dong Liu; Ming Qin; Liang-Wei Chen; Jian-Yong Qiu; Li Duan; Rong Cao; Zhi-Ren Rao; Yu-Xin Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  54     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1862-7     Citation Subset:  IM    
Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
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MeSH Terms
Acupuncture Therapy / methods*
Astrocytes / metabolism
Cell Nucleus / metabolism
Electroacupuncture / methods*
Gastrointestinal Diseases / therapy*
Glial Fibrillary Acidic Protein / metabolism
Microscopy, Fluorescence / methods
Motor Neurons / metabolism
Neurons / metabolism
Proto-Oncogene Proteins c-fos / biosynthesis
Rats, Sprague-Dawley
Stomach / metabolism
Treatment Outcome
Vagus Nerve / pathology*
Reg. No./Substance:
0/Glial Fibrillary Acidic Protein; 0/Proto-Oncogene Proteins c-fos

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