Document Detail

Electrically induced quantitative sudomotor axon reflex test in human volunteers.
MedLine Citation:
PMID:  20923721     Owner:  NLM     Status:  In-Process    
Chemically-induced quantitative sudomotor axon reflex test (QSART) and quantitative sensory testing (QST) are established clinical tools to assess thin fiber function in humans. We investigated stimulus-response functions to transcutaneous electrical stimuli of different current intensity (3.75 to 10mA) and pulse frequency (5 to 100Hz) comparing sweat output (ml/h/m(2)) and pain intensity (numeric rating scale [NRS], 0-10). Efferent sudomotor and afferent nociceptive responses were recorded after a 30s electrical stimulation period of distal (hand and foot) and proximal (forearm and thorax) body sites with 3 repetitive measures per body site. Sweat responses increased intensity dependently and peaked (~100ml/h/m(2)) at highest currents (10mA) that had been administered. Similarly, pain ratings increased with an escalating current intensity. At a constant stimulus intensity of 7.5mA, sudomotor activity was highest (~75ml/h/m(2)) at a stimulus frequency of 20Hz without further increase at 50 or 100Hz. In contrast, pain ratings increased frequency dependently and reached NRS 7 at 100Hz. Sudomotor activity, but not pain ratings, was significantly different between the body sites (p<0.05, ANOVA) with maximum sweat responses obtained at the ventral forearm. Varying response patterns for higher stimulation frequencies between sweating (peak maximum at 20Hz) and pain (maximum at 100Hz) might indicate differential axonal properties of sympathetic efferent and nociceptive afferent fibers. Electrically induced QSART could be a useful explorative and clinical method to indirectly study characteristics of frequency-dependent axonal excitability changes of sudomotor fibers.
Peter Sommer; Olga Kluschina; Marcus Schley; Barbara Namer; Martin Schmelz; Roman Rukwied
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  159     ISSN:  1872-7484     ISO Abbreviation:  Auton Neurosci     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  111-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
University Medicine Mannheim, Department of Anaesthesiology and Intensive Care Medicine, University of Heidelberg, Germany.
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