Document Detail

Electrically controlled proliferation of human carcinoma cells cultured on the surface of an electrode.
MedLine Citation:
PMID:  1367098     Owner:  NLM     Status:  MEDLINE    
Human carcinoma cells, MKN45, were cultured on the surface of a metal-coated plastic plate electrode the potential of which was controlled. The proliferation rate and cell morphology were altered depending on the applied potential. Cell proliferation was halted in the potential range above 0.4 V vs. Ag/AgCl, although cells started to proliferate again when the applied potential was shifted from 0.4 V to 0.1 V vs. Ag/AgCl. Fluorescence probe studies indicated that the fluidity of plasma membrane decreased in association with halting of cell proliferation. These results suggest that electrical stimulation causes cells to temporarily halt proliferation, and that cell proliferation was reversibly controlled by electrode potential. The mechanism is interpreted in relation to the change of plasma membrane structure represented by membrane fluidity.
J Kojima; H Shinohara; Y Ikariyama; M Aizawa; K Nagaike; S Morioka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biotechnology     Volume:  18     ISSN:  0168-1656     ISO Abbreviation:  J. Biotechnol.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-06-10     Completed Date:  1991-06-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8411927     Medline TA:  J Biotechnol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  129-39     Citation Subset:  B    
Department of Bioengineering, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo, Japan.
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MeSH Terms
Cell Division
Membrane Fluidity
Membrane Potentials
Tumor Cells, Cultured / cytology*,  physiology

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