| Electrical stimulation improves peripheral nerve regeneration in streptozotocin-induced diabetic rats. | |
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MedLine Citation:
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PMID: 22310128 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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: We discuss if percutaneous electrical stimulation (ES) at 1 mA and 2 Hz after peripheral nerve transection could enhance axonal regeneration and functional recovery in diabetic animals. METHODS:: Four groups of adult rats (group A: normal rats; group B: normal rats with ES; group C: streptozotocin- induced diabetic rats; and group D: streptozotocin-induced diabetic rats with ES) were subjected to sciatic nerve section followed by repair using silicone rubber conduits across a 10-mm gap. Rats in groups B and D received ES for 15 minutes every other day for three weeks. The groups A and C received no ES. RESULTS:: At four weeks after surgery in groups B and D, immunohistochemical staining showed that lamina I and II regions in the dorsal horn ipsilateral to the injury were significantly calcitonin gene-related peptide-immunolabeled, and a significantly higher number of macrophages were recruited in the distal sciatic nerve compared with group C. In groups A, B, and D, electrophysiological results showed higher levels of reinnervation with significantly shorter latencies and faster nerve conductive velocities, and the histologic evaluations showed relatively larger mean values of myelinated axon densities and endoneurial areas compared with group C. CONCLUSIONS:: Thus, the ES may improve the recovery of a severe peripheral nerve injury in diabetic animals, which could be considered as a supplementary treatment in diabetic neurotrauma. |
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Authors:
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Chun-Hsu Yao; Ruey-Lin Chang; Shih-Liang Chang; Chin-Chuan Tsai; Fuu-Jen Tsai; Yueh-Sheng Chen |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: The Journal of trauma Volume: 72 ISSN: 1529-8809 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: - |
Other Details:
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Languages: ENG Pagination: 199-205 Citation Subset: - |
Affiliation:
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Taichung, Taiwan From the Lab of Biomaterials (C.-H.Y., R.-L.C., F.-J.T., Y.-S.C.), School of Chinese Medicine, China Medical University, Taichung, Taiwan; Department of Biomedical Imaging and Radiological Science (C.-H.Y.), China Medical University, Taichung, Taiwan; Department of Medicinal Botanicals and Health Applications (S.-L.C.), Da-Yeh University, Changhua, Taiwan; School of Chinese Medicine for Post-Baccalaureate (C.-C.T.), I-Shou University, Kaohsiung, Taiwan; and Chinese Medicine Department (C.-C.T.), E-DA Hospital, Kaohsiung, Taiwan. |
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