| Electrical signaling in control of ocular cell behaviors. | |
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MedLine Citation:
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PMID: 22020127 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Epithelia of the cornea, lens and retina contain a vast array of ion channels and pumps. Together they produce a polarized flow of ions in and out of cells, as well as across the epithelia. These naturally occurring ion fluxes are essential to the hydration and metabolism of the ocular tissues, especially for the avascular cornea and lens. The directional transport of ions generates electric fields and currents in those tissues. Applied electric fields affect migration, division and proliferation of ocular cells which are important in homeostasis and healing of the ocular tissues. Abnormalities in any of those aspects may underlie many ocular diseases, for example chronic corneal ulcers, posterior capsule opacity after cataract surgery, and retinopathies. Electric field-inducing cellular responses, termed electrical signaling here, therefore may be an unexpected yet powerful mechanism in regulating ocular cell behavior. Both endogenous electric fields and applied electric fields could be exploited to regulate ocular cells. We aim to briefly describe the physiology of the naturally occurring electrical activities in the corneal, lens, and retinal epithelia, to provide experimental evidence of the effects of electric fields on ocular cell behaviors, and to suggest possible clinical implications. |
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Authors:
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Min Zhao; Laura Chalmers; Lin Cao; Ana C Viera; Mark Mannis; Brian Reid |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-17 |
Journal Detail:
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Title: Progress in retinal and eye research Volume: - ISSN: 1873-1635 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431859 Medline TA: Prog Retin Eye Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
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Department of Dermatology, UC Davis School of Medicine, 2921 Stockton Blvd., Room 3000, Sacramento, CA 95817, USA; Department of Ophthalmology, UC Davis School of Medicine, CA, USA; Institute for Regenerative Cures, University of California at Davis CA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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