Document Detail


Electrical resynchronization: a novel therapy for the failing right ventricle.
MedLine Citation:
PMID:  12732607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Many patients with congenital heart disease develop right ventricular (RV) failure due to anatomy and prior therapy. RV problems may include right bundle-branch block (RBBB), volume loading, and chamber enlargement. Because the failing RV may have regional dyskinesis, we hypothesized that resynchronization therapy might augment its performance. METHODS AND RESULTS: We studied 7 patients with RV dysfunction and RBBB, using a predefined pacing protocol. QRS duration, cardiac index (CI), and RV dP/dt were measured in 4 different pacing states. Atrioventricular pacing improved CI and RV dP/dtmax and decreased QRS duration as compared with atrial pacing or sinus rhythm. CONCLUSIONS: Atrioventricular pacing in patients with RBBB and RV dysfunction augments RV and systemic performance. RV resynchronization is a promising novel therapy for patients with RV failure.
Authors:
Anne M Dubin; Jeffrey A Feinstein; V Mohan Reddy; Frank L Hanley; George F Van Hare; David N Rosenthal
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-05-05
Journal Detail:
Title:  Circulation     Volume:  107     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-13     Completed Date:  2003-05-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2287-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Stanford University, 750 Welch Rd, Suite #305, Stanford, Calif 94304, USA. amdubin@leland.stanford.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Bundle-Branch Block / etiology,  therapy
Cardiac Pacing, Artificial*
Child
Child, Preschool
Electrocardiography
Female
Heart Defects, Congenital / complications
Hemodynamics
Humans
Infant
Male
Middle Aged
Ventricular Dysfunction, Right / diagnosis,  etiology,  therapy*
Ventricular Pressure
Comments/Corrections
Comment In:
Circulation. 2004 Jan 20;109(2):e5; author reply e5   [PMID:  14734508 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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