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ELECTRICAL PROPERTIES OF HYPOTHALAMIC NEUROENDOCRINE CELLS.
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MedLine Citation:
PMID:  14127607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Goldfish hypothalamic neuroendocrine cells have been investigated with intracellular recordings. The cells showed resting potentials of 50 mv and action potentials up to 117 mv followed by a long lasting and prominent diphasic hyperpolarizing afterpotential. The action potential occurred in two steps indicating sequential invasion. "Total" neuron (input) resistance was measured to be 3.3 x 10(7) ohm and total neuron time constant was 42 msec. Orthodromic volleys, produced by olfactory tract stimulation, generated graded excitatory postsynaptic potentials. These neuroendocrine cells seem, therefore, to have electrical membrane properties that are similar to those of other central neurons. Antidromic volleys (pituitary stimulation) produced inhibitory post-synaptic potentials whose latency was only slightly longer than that of the antidromic spike indicating the presence of recurrent collaterals. This finding suggests that the concept of the neuroendocrine cell as a neuron whose axon forms contacts only on blood vessels and not on other neurons or effector cells is too restrictive. Perfusion of the gills with dilute (0.3 per cent) sea water produced an inhibition of spontaneous activity. This inhibition is discussed in relation to recent work which demonstrates that goldfish hypothalamic hormones facilitate Na(+) influx across the gill membrane.
Authors:
E R KANDEL
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of general physiology     Volume:  47     ISSN:  0022-1295     ISO Abbreviation:  J. Gen. Physiol.     Publication Date:  1964 Mar 
Date Detail:
Created Date:  1964-07-01     Completed Date:  1996-12-01     Revised Date:  2010-09-21    
Medline Journal Info:
Nlm Unique ID:  2985110R     Medline TA:  J Gen Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  691-717     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Electrophysiology*
Fishes*
Hypothalamus*
Neurons*
Pituitary Gland*
Research*
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Gen Physiol
ISSN: 0022-1295
ISSN: 1540-7748
Publisher: The Rockefeller University Press
Article Information
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Copyright ©, 1964, by The Rockefeller Institute Press
Received Day: 15 Month: 7 Year: 1963
Print publication date: Day: 1 Month: 3 Year: 1964
Volume: 47 Issue: 4
First Page: 691 Last Page: 717
ID: 2195356
PubMed Id: 14127607

Electrical Properties of Hypothalamic Neuroendocrine Cells
E. R. Kandel
From the Department of Psychiatry, Harvard Medical School, and the Massachusetts Mental Health Center, Boston


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