Document Detail

Electrical power free, low dead volume, pressure-driven pumping for microfluidic applications.
MedLine Citation:
PMID:  21057609     Owner:  NLM     Status:  In-Data-Review    
This paper presents a simple-to-construct, low dead volume pump capable of generating a wide range of positive and negative pressures for microfluidic applications. The pump generates pressure or vacuum by changing the volume of air confined inside a syringe and is able to generate pressures between -95 and +300 kPa with a resolution as high as 1 Pa. Different from syringe pumps and electrokinetic pumping, which are capable of controlling flow rates only, our pump can be used to generate constant flow rates or constant pressures, which are required for certain applications such as the aspiration of biological cells for biophysical characterization. Compared to syringe pumps, the new pump has almost zero dead volume and does not exhibit pulsatile flows. Additionally, the system does not require electrical power and is cost effective (∼$100). To demonstrate the capabilities of the pump, we used it to aspirate osteoblasts (MC3T3-E1 cells) and to determine Young's modulus of the cells, to generate a concentration gradient, and to produce variable-sized droplets in microchannels using hydrodynamic focusing.
Mario Moscovici; Wei-Yin Chien; Mohamed Abdelgawad; Yu Sun
Related Documents :
8349069 - A multifunction and programmable computerized barostat.
8944949 - In vitro evaluation of automatic control performance of a total artificial heart with c...
15936619 - An expandable percutaneous catheter pump for left ventricular support: proof of concept.
8621199 - Pulse pressure correlates in humans with a proscillaridin a immunoreactive compound.
6838409 - Development and evaluation of a long-term, implantable, electrically actuated left vent...
11271019 - Plethysmography: the new wave in haemodynamic monitoring--a review of clinical applicat...
8182319 - In vitro comparison of the groningen high resistance, groningen low resistance and prov...
23408069 - A randomised trial of high and low pressure level settings on an adjustable ventriculop...
8107309 - Pressor effect of recombinant human erythropoietin: results of home blood pressure meas...
Publication Detail:
Type:  Journal Article     Date:  2010-10-13
Journal Detail:
Title:  Biomicrofluidics     Volume:  4     ISSN:  1932-1058     ISO Abbreviation:  Biomicrofluidics     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101293825     Medline TA:  Biomicrofluidics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  46501     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  MRI-Compatible Pneumatic Robot for Transperineal Prostate Needle Placement.
Next Document:  Prevention of pain with the injection of microemulsion propofol: a comparison of a combination of li...