Document Detail

Electrical and mechanical uterine activity and gap junctions in peripartal sheep.
MedLine Citation:
PMID:  4050919     Owner:  NLM     Status:  MEDLINE    
In 10 chronically instrumented pregnant ewes myometrial electrical activity and intrauterine pressure were measured and plasma levels of 17 beta-estradiol and progesterone were determined in late pregnancy and during and after labor. Myometrial biopsies were obtained to determine gap junction area. Plasma progesterone levels fell 4 days before delivery, and 17 beta-estradiol levels rose sharply 12 hours before delivery. Toward delivery the myometrial electrical pattern changed from infrequent bursts of long duration to frequent bursts of short duration, and the active pressure area of the intrauterine pressure cycles, the apparent conduction velocity, and the rate of rise of intrauterine pressure cycles increased associated with the changes in hormone levels. These changes were related to an increase in gap junction area. It is concluded that these results support the hypothesis that changes in concentrations of steroid hormones lead to an increase in myometrial gap junction area, which improves the coordination of contractile activity of the uterus during labor.
A Verhoeff; R E Garfield; J Ramondt; H C Wallenburg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  153     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-11-15     Completed Date:  1985-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  447-54     Citation Subset:  AIM; IM    
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MeSH Terms
Estradiol / blood
Intercellular Junctions / physiology*
Labor, Obstetric
Myometrium / physiology*
Neural Conduction
Pregnancy, Animal*
Progesterone / blood
Sheep / physiology*
Uterine Contraction*
Reg. No./Substance:
50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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