| Electrical and mechanical responses in the platysma and in the adductor pollicis muscle: in patients with myasthenia gravis. | |
| | |
MedLine Citation:
|
PMID: 196048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Electrical and mechanical muscular responses to single and repetitive stimuli were recorded in 24 patients with myasthenia gravis. Findings in the platysma were compared with those in m. adductor pollicis (ADP). In the platysma, but not in the ADP, electrical and mechanical responses to single stimuli were often lower than normal, and could be normalised after tetanus and by endrophonium. The decrement of electrical and mechanical responses to repetitive stimuli was two to three times greater in the platysma than in the ADP; post-tetanic facilitation of the action potential was four times greater. The staircase phenomenon was abnormal in the platysma in patients with moderate and severe myasthenia, and also in the ADP in some patients without decrement in the action potential. Edrophonium was more effective in alleviating decrement in the platysma than in the ADP. In the platysma, block of neuromuscular transmission could account for most abnormalities. The finding in some patients of an abnormal staircase after correction for block of fibres indicates a lesion in excitation-contraction coupling. In six patients only the platysma showed abnormalities, in 10 patients abnormalities were more pronounced in the platysma than in the ADP, and in three patients more pronounced in the ADP than in the platysma; in five patients the platysma and the ADP were equally affected. |
| | |
Authors:
|
C Krarup |
Related Documents
:
|
22398858 - A combined pharmacometric analysis of dabigatran etexilate in healthy volunteers and pa... 84468 - Porphyria cutanea tarda associated with lymphoma. 18487558 - Spontaneous recovery of dermatomyositis and unspecified myositis in three adult patients. 16178018 - A ctla4high genotype is associated with myasthenia gravis in thymoma patients. 15887588 - Dysfunction of the pisotriquetral joint: degenerative arthritis treated by excision of ... 12106728 - Characterization of visual phenomena with the array multifocal intraocular lens. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of neurology, neurosurgery, and psychiatry Volume: 40 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 1977 Mar |
Date Detail:
|
Created Date: 1977-09-29 Completed Date: 1977-09-29 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 241-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Edrophonium / therapeutic use Evoked Potentials* Female Humans Middle Aged Muscle Contraction Muscles / physiopathology* Myasthenia Gravis / drug therapy, physiopathology* Neck Synaptic Transmission Thumb* |
| Chemical | |
Reg. No./Substance:
|
312-48-1/Edrophonium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antiviral activity in the rabbit cornea of adenine arabinoside, Ara-A 5' monophosphate, and hypoxant...
Next Document: Value of exchangeable electrolyte measurement in the treatment of myasthenia gravis.