Document Detail


Electrical and mechanical dyssynchrony in pediatric pulmonary hypertension.
MedLine Citation:
PMID:  22682994     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Electrical and mechanical dyssynchrony are often seen in patients with left ventricular failure. In pediatric pulmonary hypertension (PH), right ventricular failure predominates; however, the prevalence of electrical and/or mechanical dyssynchrony in these patients is unknown. We examined the prevalence of electrical and mechanical dyssynchrony in pediatric PH patients. METHODS: Medical records (including, functional status, electrocardiograms and echocardiograms) of pediatric PH patients were reviewed. QRS duration z-scores were calculated to determine electrical dyssynchrony. Echo vector velocity imaging was used to calculate the mechanical dyssynchrony index (DI). RESULTS: Seventy-seven PH patients (idiopathic pulmonary arterial hypertension [IPAH]: n = 26; congenital heart disease: n = 41; other: n = 10) were studied. Electrical dyssynchrony was seen in 84% (p < 0.01 vs historic controls), with a mean z-score of 4.3 (95% CI 3.5 to 5.1). There was no difference between those with IPAH, z = 3.6 (95% CI 2.5 to 4.6), and those without, z = 4.7 (95% CI 3.6 to 5.8). Mechanical dyssynchrony was seen in 76% of patients (mean DI = 66 ± 47 vs 18 ± 8 milliseconds in historic controls, p < 0.01) in both IPAH and non-IPAH patients. Post-operative congenital heart disease patients had the largest dyssynchrony index. No correlation was found among electrical or mechanical dyssynchrony, hemodynamics or disease severity. CONCLUSIONS: Significant electrical and mechanical dyssynchrony is present in pediatric PH patients, regardless of etiology. The overall effect of electrical and mechanical dyssynchrony on outcomes in this patient population is still unknown. Select patients may benefit from resynchronization therapy.
Authors:
Allison C Hill; Dawn M Maxey; David N Rosenthal; Stephanie L Siehr; Seth A Hollander; Jeffrey A Feinstein; Anne M Dubin
Related Documents :
8286224 - Immunological evaluation of erythema nodosum in tularaemia.
10611624 - Response of patients with igm and iga-associated peripheral polyneuropathies to "off-li...
6681124 - Immunologic abnormalities in idiopathic raynaud's phenomenon.
11830434 - Deficiency of complement-dependent prevention of immune precipitation in systemic scler...
19428124 - Autoantibodies to glutamic acid decarboxylase (gad) in focal and generalized epilepsy: ...
3571484 - Pseudomonas sp. group ve-2 bacterial peritonitis in a patient on continuous ambulatory ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-7
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  -     ISSN:  1557-3117     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Pediatrics, Division of Cardiology, Stanford University Medical School, Palo Alto, California.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Polyamine-modulated factor-1 methylation predicts Bacillus Calmette-Guérin response in patients wit...
Next Document:  Validation of a Spanish version of the Muscle Appearance Satisfaction Scale: Escala de Satisfacción...