| Electrical injury in the femoral artery of rabbits as a model for arterial thrombosis: a pilot study. | |
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MedLine Citation:
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PMID: 8161008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Electrical stimulation was delivered to the femoral artery of 20 rabbits to examine whether endothelial injury results in a consistent formation of arterial thrombosis. The arterial patency was monitored throughout the experiment by flowmeter and was visualized by femoral angiography in 5/20 cases. The arterial segments remained totally occluded in 7/20 (35%), partially occluded in 9/20 (45%), and patent in 4/20 (20%) rabbits following stimulation with 200 microA anodal current for 180 minutes. The average time of electrical stimulation needed to achieve total occlusion (n = 7) was 110 +/- 49 minutes. Alternating occlusion and recanalization of the artery (cyclic flow variation) was observed in 12 rabbits, with total occlusion ensuing in 6/12 cases. Intravenous administration of recombinant tissue-type plasminogen activator (20 micrograms/kg/min for sixty minutes) resulted in femoral reflow and subsequent reocclusion in 2/5 cases. Histopathologic examination disclosed arterial thrombi composed of platelets, fibrin, and red blood cells. Thus, according to these data this technique was found to induce arterial thrombosis following electrical stimulation of the rabbit femoral artery but was inconsistent regarding the arterial patency. |
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Authors:
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R Kornowski; M Glikson; D Ohad; N Varda-Bloom; A Battler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Angiology Volume: 45 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-05-19 Completed Date: 1994-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 295-300 Citation Subset: IM |
Affiliation:
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Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterial Occlusive Diseases / etiology*, pathology Disease Models, Animal Electric Injuries / complications* Electric Stimulation Femoral Artery / injuries* Pilot Projects Rabbits Thrombosis / etiology*, pathology Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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