| Electrical injury and amyotrophic lateral sclerosis: a systematic review of the literature. | |
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MedLine Citation:
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PMID: 17098839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Electrical injury may act as a potential precipitating or risk factor for amyotrophic lateral sclerosis (ALS). A systematic review of the literature was undertaken to assess the relationship between electrical injury and the development of ALS. Information for the review was obtained using five medical databases, and from manual searching of individual papers. Patients presenting with a neurological syndrome after electrical injury, including lightning, were included and classified into four categories: ALS; progressive upper motor neurone (UMN) syndrome; progressive lower motor neurone (LMN) syndrome; and non-progressive syndrome. Linear regression and chi2 testing were used for analysis of the data. 96 individuals, comprising 44 with ALS, 1 with a progressive UMN syndrome, 7 with a progressive LMN syndrome and 44 with a non-progressive syndrome, were identified from 31 papers with publication dates between 1906 and 2002. The median interval between electrical injury and disease onset was 2.25 years for all progressive syndromes and just over 1 week for the non-progressive syndrome. The more severe the shock (excluding lightning), the more likely individuals were to have a non-progressive motor syndrome. A non-progressive spinal cord syndrome is associated with more severe electrical injury. Overall, the evidence reviewed does not support a causal relationship between ALS and electric shock. |
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Authors:
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Kumar Abhinav; Ammar Al-Chalabi; Tibor Hortobagyi; P Nigel Leigh |
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Publication Detail:
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Type: Journal Article; Review Date: 2006-11-10 |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 78 ISSN: 1468-330X ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-16 Completed Date: 2007-04-19 Revised Date: 2010-09-14 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 450-3 Citation Subset: IM |
Affiliation:
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Queen Elizabeth Hospital, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amyotrophic Lateral Sclerosis
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epidemiology,
etiology* Electric Injuries / complications* Humans Motor Skills Disorders / epidemiology, etiology* Risk Factors Syndrome Time Factors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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