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Electrical excitability of the heart in a Chondrostei fish, the Siberian sturgeon (Acipenser baerii).
MedLine Citation:
PMID:  25163915     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
To extend our knowledge of fish cardiac excitability to a Chondrostei fish, we examined electrophysiological phenotype of the Siberian sturgeon (Acipenser baerii) heart. Epicardial ECG of A.baerii had typical waveform of vertebrate ECG with Q-T interval of 650 ± 30 ms and an intrinsic heart rate of 45.5 ± 5 beats min(-1) at 20°C. Similar to other fish species atrial AP was shorter in duration (402 ± 33 ms) than ventricular AP (585 ± 40) (P<0.05) at 20°C. Densities of atrial and ventricular Na(+) currents were similar (-47.6 ± 4.5 and -53.2 ± 5.1 pA pF(-1), respectively) and close to the typical values of teleost hearts. The atrial IKr (3.3 ± 0.2 pA pF(-1)) was about twice as large as the ventricular IKr (1.3 ± 0.4 pA pF(-1)) (P<0.05) conforming to the pattern of teleost cardiac IKr. Divergent from other fishes the ventricular IK1 was remarkably small (-2.5 ± 0.07 pA pF(-1)) and not different from that of the atrial myocytes (-1.9 ± 0.06 pA pF(-1)) (P>0.05). The most striking difference to other fishes appeared in Ca(2+) currents (ICa). In atrial myocytes ICa was predominated by nickel-sensitive and nifedipine-resistant T-type ICa, while ventricular myocytes had mainly nifedipine-sensitive and nickel-resistant L-type ICa. ICaT/ICaL ratio of the sturgeon atrial myocytes (2.42) is the highest value ever measured for a vertebrate species. With the exception of the large atrial ICaT and small ventricular IK1 electrical excitability of A. baerii heart is similar to that of teleost hearts.
Authors:
Thomas Eliot Haworth; Jaakko Haverinen; Holly A Shiels; Matti Vornanen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-27
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology.
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