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Electrical coupling between embryonic cells by way of extracellular space and specialized junctions.
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MedLine Citation:
PMID:  5415239     Owner:  NLM     Status:  MEDLINE    
The meroblastic egg of the teleost, Fundulus heteroclitus, was studied electrophysiologically from cleavage to mid-gastrula stages. The yolk is an intracellular inclusion surrounded by a membrane of high resistivity (50 k ohmcm(2)). This membrane generates a cytoplasm-negative resting potential in later stages. Cells of all stages studied are coupled electrically. In gastrulae, coupling is both by way of specialized junctions between cells and by way of intra-embryonic extracellular space, the segmentation cavity. The latter mode is present because the segmentation cavity is sealed off from the exterior by a high resistance barrier, and the outer membrane of surface cells is of high resistance (50-100 k ohmcm(2)) compared to the inner membrane. It can be inferred that clefts between surface cells are occluded by circumferential junctions. Isolated cells from late cleavage stages develop coupling in vitro, confirming the existence of coupling by way of intercellular junctions. Both modes of coupling could mediate communication between cells that is important in embryonic development.
M V Bennett; J P Trinkaus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of cell biology     Volume:  44     ISSN:  0021-9525     ISO Abbreviation:  J. Cell Biol.     Publication Date:  1970 Mar 
Date Detail:
Created Date:  1970-04-03     Completed Date:  1970-04-03     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  0375356     Medline TA:  J Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  592-610     Citation Subset:  IM    
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MeSH Terms
Biological Transport, Active
Cell Membrane Permeability*
Electron Transport
Embryo, Nonmammalian / cytology*
Fishes / embryology
Membrane Potentials*
Models, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): J Cell Biol
ISSN: 0021-9525
ISSN: 1540-8140
Publisher: The Rockefeller University Press
Article Information
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Copyright © 1970 by The Rockefeller University Press
Received Day: 12 Month: 8 Year: 1969
Revision Received Day: 15 Month: 10 Year: 1969
Print publication date: Day: 1 Month: 3 Year: 1970
Volume: 44 Issue: 3
First Page: 592 Last Page: 610
ID: 2107981
PubMed Id: 5415239

M. V. L. Bennett
J. P. Trinkaus
From the Department of Anatomy, Albert Einstein College of Medicine, New York, New York 10461, the Department of Biology, Yale University, New Haven, Connecticut 06520, and the Marine Biological Laboratory, Woods Hole, Massachusetts 02543

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