| Electrical bioimpedance gastric motility measurement based on an electrical-mechanical composite mechanism. | |
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MedLine Citation:
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PMID: 22783053 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To introduce a bioimpedance gastric motility measurement method based on an electrical-mechanical composite concept and a preliminary clinical application. METHODS: A noninvasive gastric motility measurement method combining electrogastrogram (EGG) and impedance gastric motility (IGM) test was used. Preliminary clinical application studies of patients with functional dyspepsia (FD) and gastritis, as well as healthy controls, were carried out. Twenty-eight FD patients (mean age 40.9 ± 9.7 years) and 40 healthy volunteers (mean age 30.9 ± 7.9 years) were involved. IGM spectrum was measured for both the healthy subjects and FD patients, and outcomes were compared in the FD patients before treatment and 1 wk and 3 wk after treatment. IGM parameters were obtained from 30 erosive gastritis patients (mean age 50.5 ± 13.0 years) and 40 healthy adults, and IGM and EGG results were compared in the gastritis patients before treatment and 1 wk after treatment. RESULTS: There were significant differences in the IGM parameters between the FD patients and healthy subjects, and FD patients had a poorer gastric motility [percentage of normal frequency (PNF) 70.8 ± 25.5 in healthy subjects and 28.3 ± 16.9 in FD patients, P < 0.01]. After 1 wk administration of domperidone 10 mg, tid, the gastric motility of FD patients was not improved, although the EGG of the patients had returned to normal. After 3 wk of treatment, the IGM rhythm of the FD patients became normal. There was a significant difference in IGM parameters between the two groups (PNF 70.4 ± 25.5 for healthy subjects and 36.1 ± 21.8 for gastritis patients, P < 0.05). The EGG rhythm of the gastritis patients returned to normal (frequency instability coefficient 2.22 ± 0.43 before treatment and 1.77 ± 0.19 one wk after treatment, P < 0.05) after 1 wk of treatment with sodium rabeprazole tablets, 10 mg, qd, po, qm, while some IGM parameters showed a tendency toward improvement but had not reached statistical significance. CONCLUSION: The electrical-mechanical composite measurement method showed an attractive clinical application prospect in gastric motility research and evaluation. |
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Authors:
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Shu Zhao; Hong Sha; Zhang-Yong Li; Chao-Shi Ren |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 18 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-07-11 Completed Date: 2012-11-21 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 3282-7 Citation Subset: IM |
Affiliation:
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Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China. |
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| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles
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therapeutic use Adult Case-Control Studies China Domperidone / therapeutic use Dopamine Antagonists / therapeutic use Dyspepsia / diagnosis*, drug therapy, physiopathology Electric Impedance Electrodiagnosis* / methods Feasibility Studies Gastritis / diagnosis*, drug therapy, physiopathology Gastrointestinal Motility* / drug effects Humans Middle Aged Predictive Value of Tests Proton Pump Inhibitors / therapeutic use Stomach / drug effects, physiopathology* Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Dopamine Antagonists; 0/Proton Pump Inhibitors; 32828355LL/rabeprazole; 57808-66-9/Domperidone |
| Comments/Corrections | |
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