Document Detail


Electrical bioimpedance gastric motility measurement based on an electrical-mechanical composite mechanism.
MedLine Citation:
PMID:  22783053     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To introduce a bioimpedance gastric motility measurement method based on an electrical-mechanical composite concept and a preliminary clinical application.
METHODS: A noninvasive gastric motility measurement method combining electrogastrogram (EGG) and impedance gastric motility (IGM) test was used. Preliminary clinical application studies of patients with functional dyspepsia (FD) and gastritis, as well as healthy controls, were carried out. Twenty-eight FD patients (mean age 40.9 ± 9.7 years) and 40 healthy volunteers (mean age 30.9 ± 7.9 years) were involved. IGM spectrum was measured for both the healthy subjects and FD patients, and outcomes were compared in the FD patients before treatment and 1 wk and 3 wk after treatment. IGM parameters were obtained from 30 erosive gastritis patients (mean age 50.5 ± 13.0 years) and 40 healthy adults, and IGM and EGG results were compared in the gastritis patients before treatment and 1 wk after treatment.
RESULTS: There were significant differences in the IGM parameters between the FD patients and healthy subjects, and FD patients had a poorer gastric motility [percentage of normal frequency (PNF) 70.8 ± 25.5 in healthy subjects and 28.3 ± 16.9 in FD patients, P < 0.01]. After 1 wk administration of domperidone 10 mg, tid, the gastric motility of FD patients was not improved, although the EGG of the patients had returned to normal. After 3 wk of treatment, the IGM rhythm of the FD patients became normal. There was a significant difference in IGM parameters between the two groups (PNF 70.4 ± 25.5 for healthy subjects and 36.1 ± 21.8 for gastritis patients, P < 0.05). The EGG rhythm of the gastritis patients returned to normal (frequency instability coefficient 2.22 ± 0.43 before treatment and 1.77 ± 0.19 one wk after treatment, P < 0.05) after 1 wk of treatment with sodium rabeprazole tablets, 10 mg, qd, po, qm, while some IGM parameters showed a tendency toward improvement but had not reached statistical significance.
CONCLUSION: The electrical-mechanical composite measurement method showed an attractive clinical application prospect in gastric motility research and evaluation.
Authors:
Shu Zhao; Hong Sha; Zhang-Yong Li; Chao-Shi Ren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  18     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-11     Completed Date:  2012-11-21     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  3282-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
2-Pyridinylmethylsulfinylbenzimidazoles / therapeutic use
Adult
Case-Control Studies
China
Domperidone / therapeutic use
Dopamine Antagonists / therapeutic use
Dyspepsia / diagnosis*,  drug therapy,  physiopathology
Electric Impedance
Electrodiagnosis* / methods
Feasibility Studies
Gastritis / diagnosis*,  drug therapy,  physiopathology
Gastrointestinal Motility* / drug effects
Humans
Middle Aged
Predictive Value of Tests
Proton Pump Inhibitors / therapeutic use
Rabeprazole
Stomach / drug effects,  physiopathology*
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Dopamine Antagonists; 0/Proton Pump Inhibitors; 32828355LL/Rabeprazole; 5587267Z69/Domperidone
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