Document Detail


Electrical communication in branching arterial networks.
MedLine Citation:
PMID:  22796538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Electrical communication and its role in blood flow regulation are built on an examination of charge movement in single, isolated vessels. How this process behaves in broader arterial networks remains unclear. This study examined the nature of electrical communication in arterial structures where vessel length and branching were varied. Analysis began with the deployment of an existing computational model expanded to form a variable range of vessel structures. Initial simulations revealed that focal endothelial stimulation generated electrical responses that conducted robustly along short unbranched vessels and to a lesser degree lengthened arteries or branching structures retaining a single branch point. These predictions matched functional observations from hamster mesenteric arteries and support the idea that an increased number of vascular cells attenuate conduction by augmenting electrical load. Expanding the virtual network to 31 branches revealed that electrical responses increasingly ascended from fifth- to first-order arteries when the number of stimulated distal vessels rose. This property enabled the vascular network to grade vasodilation and network perfusion as revealed through blood flow modeling. An elevation in endothelial-endothelial coupling resistance, akin to those in sepsis models, compromised this ascension of vasomotor/perfusion responses. A comparable change was not observed when the endothelium was focally disrupted to mimic disease states including atherosclerosis. In closing, this study highlights that vessel length and branching play a role in setting the conduction of electrical phenomenon along resistance arteries and within networks. It also emphasizes that modest changes in endothelial function can, under certain scenarios, impinge on network responsiveness and blood flow control.
Authors:
Cam Ha T Tran; Edward J Vigmond; Daniel Goldman; France Plane; Donald G Welsh
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Publication Detail:
Type:  Journal Article     Date:  2012-07-13
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  303     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-17     Completed Date:  2012-11-23     Revised Date:  2013-09-19    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H680-92     Citation Subset:  IM    
Affiliation:
Hotchkiss Brain and Libin Cardiovascular Research Institute, University of Calgary, Alberta, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Communication*
Computer Simulation
Cricetinae
Electric Conductivity
Electric Stimulation
Endothelial Cells / physiology
Gap Junctions / physiology
Hemodynamics*
Homeostasis
Male
Membrane Potentials
Mesenteric Arteries / anatomy & histology,  physiology*
Mesocricetus
Models, Cardiovascular
Myocytes, Smooth Muscle / physiology
Myography
Regional Blood Flow
Splanchnic Circulation
Vascular Diseases / pathology,  physiopathology
Vasodilation
Grant Support
ID/Acronym/Agency:
R01 HL101196/HL/NHLBI NIH HHS
Comments/Corrections

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