Document Detail


Electric synapses in the carotid body-nerve complex.
MedLine Citation:
PMID:  17336600     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Slices of rat carotid bodies, or cultured glomus cells, were used to study intercellular coupling. This phenomenon occurs because gap junctions allow passage of currents and dyes from one cell to another. There is a two-way resistive coupling between glomus cells (GC/GC coupling), which is accompanied by activity of intercellular channels. Coupling between glomus cells and nerve endings is more complex. Coupling is mostly resistive from cell to nerve (GC/NE) but it is mostly capacitive in the opposite direction (NE/GC). Thus, slow electric events originating in the glomus cells can be transferred to the nerve endings. But, only electric transients can pass from nerve to cell. There is also coupling between nerve endings (NE/NE), which is mostly capacitive in either direction. Chemoreceptor stimulants (acute and chronic hypoxia, hypercapnia, acidity, cholinergic agents and dopamine) uncouple most glomus cells, accompanied by cell depolarization and decreased amplitude of junction channels. Chronic hypobaric hypoxia increases GC/NE, NE/GC and NE/NE coupling. GC/GC uncoupling seems related to transmitter secretion. Transmission across chemical synapses is aided by increased coupling from glomus cell to nerve ending.
Authors:
Carlos Eyzaguirre
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2007-01-30
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  157     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-04-27     Completed Date:  2007-07-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  116-22     Citation Subset:  IM    
Affiliation:
Department of Physiology, School of Medicine, University of Utah, Salt Lake City, UT 84108, USA. cee3@utah.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Carotid Body / cytology*,  physiology*
Cell Communication / physiology*
Chemoreceptor Cells / cytology,  physiology
Gap Junctions / physiology*
Humans
Synapses / physiology*
Grant Support
ID/Acronym/Agency:
NS07938/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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