Document Detail

Electocardiographic findings in adult Nigerians with sickle cell anaemia.
MedLine Citation:
PMID:  21327134     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cardiovascular system abnormalities are common causes of morbidity and mortality in sickle cell anaemia.
OBJECTIVES: The study aims at determining the pattern of electrocardiographic changes in adult Nigerian sickle cell anaemia patients.
METHODS: A descriptive cross sectional study was done on sixty sickle cell anaemia patients seen at the adult sickle cell clinic of University of Nigeria Teaching Hospital (UNTH) Enugu, and sixty age and sex matched normal controls. All the subjects had clinical evaluation as well as electrocardiographic examination.
RESULTS: The mean heart rate, P-wave duration, P-wave dispersion, PR interval, QRS duration, QRS dispersion, QTc interval and QTc dispersion were significantly higher in the patients than in the control group. Electrocardiographic abnormalities identified by this study were: left ventricular hypertrophy (75%; 1.7%), left atrial enlargement (40%; 0%), biventricular hypertrophy (11%; 0), ST-segment elevation (10%; 0%) and increased P-wave and QTc dispersions. ST segment elevation was found more in patients with moderate and severe anaemia (P= 0.02, Spearman correlation r= 0.342; P= 0.007),
CONCLUSION: Sickle cell anaemia is associated with significant electrocardiographic abnormalities. Further prospective studies are recommended to evaluate the prognostic significance of the electrocardiographic intervals dispersion on the long term disease outcome in sickle cell anaemia.
N I Oguanobi; B J C Onwubere; S O Ike; B C Anisiuba; E C Ejim; O G Ibegbulam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  African health sciences     Volume:  10     ISSN:  1729-0503     ISO Abbreviation:  Afr Health Sci     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2011-02-17     Completed Date:  2011-04-27     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101149451     Medline TA:  Afr Health Sci     Country:  Uganda    
Other Details:
Languages:  eng     Pagination:  235-41     Citation Subset:  IM    
Department of Medicine, University of Nigeria Teaching Hospital Enugu, Nigeria.
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MeSH Terms
African Continental Ancestry Group
Anemia, Sickle Cell / complications*,  epidemiology
Cardiovascular Abnormalities / complications,  epidemiology,  physiopathology*
Cardiovascular Diseases / etiology
Case-Control Studies
Cross-Sectional Studies
Electrocardiography / methods*
Hospitals, Teaching
Middle Aged
Nigeria / epidemiology
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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