Document Detail


Elective subtotal splenectomy. Indications and results in 33 patients.
MedLine Citation:
PMID:  2294841     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Elective subtotal splenectomy was performed in 33 patients (30 children and 3 adults) between 1981 and 1989. Indications for the procedure were (1) prevention of azathioprine-induced neutropenia (n = 20); (2) Type I Gaucher disease (n = 9); and (3) cholesteryl ester storage disease, chronic myelogenous leukemia, thalassemia major, and splenic cyst in one patient each. There were no operative deaths, no reoperations for bleeding, and 30 of 33 (91%) patients had a functioning splenic remnant documented by a postoperative radionuclide spleen scan. One patient developed neutropenia without evidence of viral infection that required temporary cessation of azathioprine and the patient with thalassemia major had only transient improvement in transfusion requirements. All other patients (94%) had control of the underlying condition for which the operation was performed. We conclude that subtotal splenectomy is a safe, effective therapy for a variety of nontraumatic conditions.
Authors:
P C Guzzetta; E J Ruley; H F Merrick; C Verderese; N Barton
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of surgery     Volume:  211     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-06     Completed Date:  1990-02-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  34-42     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, Children's Hospital National Medical Center, Washington, D.C. 20010.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Azathioprine / adverse effects
Child
Child, Preschool
Gaucher Disease / surgery
Humans
Infant
Neutropenia / chemically induced,  prevention & control
Spleen / physiopathology
Splenectomy / adverse effects,  methods*
Splenomegaly / surgery
Chemical
Reg. No./Substance:
446-86-6/Azathioprine
Comments/Corrections

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