Document Detail


Elective single cleavage-stage embryo transfer need not result in lower pregnancy rates compared to double cleavage-stage embryo transfer.
MedLine Citation:
PMID:  20666945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To confirm whether women who choose to have one fresh embryo transferred and one frozen-and-thawed embryo when needed can dramatically reduce the possibility of a multifetal pregnancy while giving themselves a better chance of achieving pregnancy.
METHODS: We enrolled 685 patients who were undergoing assisted reproductive technology (ART) treatment at our clinic between January 2005 and December 2008. None of the patients had a history of ART treatment, and they received either a double-embryo transfer (DET) or single-embryo transfer (SET) during this period. The outcomes of the ART and the pregnancy rates per patient were evaluated for both groups and comparisons were made.
RESULTS: The mean age was 35.7 +/- 0.2 years (mean +/- standard error of the mean) for all patients (n = 583) who received a fresh embryo cycle of DET. In contrast, the mean age (34.3 +/- 0.4) of all patients (n = 102) who received a fresh- or thawed-embryo transfer cycle of SET was significantly younger than the average age in the DET group (P < 0.05). The per-patient overall pregnancy rate in the SET group was an estimated 35.3%, which was significantly higher than that in the DET group (P = 0.02). However, the multifetal pregnancy rate for the DET group was significantly higher than that for the SET group (P < 0.01).
CONCLUSION: We demonstrated that women who choose to have one fresh embryo transferred and one frozen-and-thawed embryo when needed, can dramatically reduce their possibility of a multifetal pregnancy while giving themselves a better chance of achieving pregnancy.
Authors:
Koji Nakagawa; Yayoi Nishi; Rie Sugiyama; Yasushi Kuribayashi; Rikikazu Sugiyama; Masato Inoue
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  36     ISSN:  1447-0756     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-29     Completed Date:  2010-11-04     Revised Date:  2012-01-19    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  777-82     Citation Subset:  IM    
Affiliation:
Division of Reproductive Medicine, Sugiyama Clinic, Setagaya, Tokyo, Japan. koji@sugiyama.or.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Chi-Square Distribution
Embryo Transfer / methods*
Female
Fertilization in Vitro
Humans
Pregnancy
Pregnancy Rate
Pregnancy, Multiple
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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