Document Detail

Elective gastrostomy, nutritional status and quality of life in advanced head and neck cancer patients receiving chemoradiotherapy.
MedLine Citation:
PMID:  19878166     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chemoradiotherapy for treatment of advanced head and neck cancer (HNC) is used to achieve organ preservation without compromising survival. Because chemoradiotherapy usually impacts adversely on nutritional and functional status, feeding by percutaneous endoscopic gastrostomy (PEG) is often part of the management regimen for these patients, but the presence of a PEG tube can also be associated with reduced quality of life (QOL). This study aimed to examine the factors associated with PEG insertion and the effects of PEG use on QOL and functional outcomes in HNC patients receiving chemoradiotherapy. METHOD: Survey of 36 consecutive patients treated by primary chemoradiotherapy for HNC. Patient weight, age, tumour type, details of PEG insertion, feeding regimens and treatment were noted. The survey comprised the Performance Status Scale, the Functional Measure for Swallowing, Nutritional Mode and a self-assessment of QOL. RESULTS: PEG insertion within 1 month of treatment was associated with smaller fall in body mass index at 12 months than PEG insertion 1 month or more after the start of the treatment (P < 0.05). Body mass index change was inversely correlated with health-related quality of life and significantly related to lower speech and swallowing function scores. Longer PEG duration correlated with poorer performance status and swallowing function (P < 0.01). Longer PEG duration also predicted poorer overall QOL (P < 0.01) and poorer swallowing (P < 0.01) and speech (P < 0.05). Nutritional mode was related to overall QOL (P < 0.01). CONCLUSIONS: Nutritional support for HNC patients undergoing chemoradiotherapy is an essential component of patient care. Early PEG insertion and shorter PEG duration are associated with more favourable QOL-related outcomes.
Randall P Morton; Victoria L Crowder; Robert Mawdsley; Esther Ong; Mark Izzard
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  ANZ journal of surgery     Volume:  79     ISSN:  1445-2197     ISO Abbreviation:  ANZ J Surg     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-02     Completed Date:  2010-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101086634     Medline TA:  ANZ J Surg     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  713-8     Citation Subset:  IM    
Department of Otolaryngology - Head and Neck Surgery, Counties - Manukau District Health Board, Manukau, New Zealand.
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MeSH Terms
Antineoplastic Agents / therapeutic use*
Enteral Nutrition / methods*
Follow-Up Studies
Gastrostomy / methods*
Head and Neck Neoplasms / drug therapy,  radiotherapy,  surgery*
Middle Aged
Nutritional Status*
Quality of Life*
Radiotherapy, Adjuvant
Retrospective Studies
Surgical Procedures, Elective / methods*
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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