Document Detail

Elastomeric surgical sealant for hemostasis of cardiovascular anastomosis under full heparinization.
MedLine Citation:
PMID:  17765567     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We developed a novel surgical sealant, a viscous diisocyanated prepolymer, applicable to arterial hemostasis. The purpose of this study is to evaluate hemostatic effect of this surgical sealant under heparinized conditions. METHODS: The effectiveness of this sealant was verified by applying it to the end-to-end anastomosis of canine carotid arteries. Five mongrel dogs were used. After a complete heparinization, the carotid arteries were clamped, divided, and end-to-end anastomoses were performed with four simple interrupted sutures. The sealant was coated on the anastomosis. After 5 min the clamps were removed and the hemostatic effect was evaluated. Three dogs were immediately subjected to macroscopic evaluation. Two dogs were subjected to angiography after 3 months and 16 months, respectively. RESULTS: No bleeding occurred in any of the anastomoses immediately after the removal of the clamp. Macroscopic finding revealed no leakage of the sealant into the lumen. Carotid angiography revealed patent anastomoses without stenosis. CONCLUSION: A novel surgical sealant exhibited rapid and potent hemostatic effect on a moisturized tissue under full heparinization.
Masataka Eto; Shigeki Morita; Masakazu Sugiura; Tetsuji Yoshimura; Ryuji Tominaga; Takehisa Matsuda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-31
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  32     ISSN:  1010-7940     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-09     Completed Date:  2008-02-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  730-4     Citation Subset:  IM    
Division of Cardiovascular Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka 812-8582, Japan.
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MeSH Terms
Anastomosis, Surgical / methods
Blood Loss, Surgical / prevention & control*
Cardiovascular Surgical Procedures / methods*
Hemorrhage / prevention & control
Hemostasis, Surgical / methods*
Models, Animal
Polymers / standards*
Postoperative Hemorrhage / prevention & control
Tissue Adhesives / standards*
Reg. No./Substance:
0/Polymers; 0/Tissue Adhesives; 0/elastomeric

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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