Document Detail


Elastomeric electrospun scaffolds of poly(L: -lactide-co-trimethylene carbonate) for myocardial tissue engineering.
MedLine Citation:
PMID:  21617996     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In myocardial tissue engineering the use of synthetically bioengineered flexible patches implanted in the infarcted area is considered one of the promising strategy for cardiac repair. In this work the potentialities of a biomimetic electrospun scaffold made of a commercial copolymer of (L: )-lactic acid with trimethylene carbonate (P(L: )LA-co-TMC) are investigated in comparison to electrospun poly(L: )lactic acid. The P(L: )LA-co-TMC scaffold used in this work is a glassy rigid material at room temperature while it is a rubbery soft material at 37°C. Mechanical characterization results (tensile stress-strain and creep-recovery measurements) show that at 37°C electrospun P(L: )LA-co-TMC displays an elastic modulus of around 20 MPa and the ability to completely recover up to 10% of deformation. Cell culture experiments show that P(L: )LA-co-TMC scaffold promotes cardiomyocyte proliferation and efficiently preserve cell morphology, without hampering expression of sarcomeric alpha actinin marker, thus demonstrating its potentialities as synthetic biomaterial for myocardial tissue engineering.
Authors:
Shayanti Mukherjee; Chiara Gualandi; Maria Letizia Focarete; Rajeswari Ravichandran; Jayarama Reddy Venugopal; Michael Raghunath; Seeram Ramakrishna
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-27
Journal Detail:
Title:  Journal of materials science. Materials in medicine     Volume:  -     ISSN:  1573-4838     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013087     Medline TA:  J Mater Sci Mater Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Bioengineering, National University of Singapore, Singapore, Singapore.
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