| Elastohydrodynamic separation of pleural surfaces during breathing. | |
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MedLine Citation:
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PMID: 12871681 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine effects of lung motion on the separation of pleural surfaces during breathing, we modeled the pleural space in two dimensions as a thin layer of fluid separating a stationary elastic solid and a sliding flat solid surface. The undeformed elastic solid contained a series of bumps, to represent tissue surface features, introducing unevenness in fluid layer thickness. We computed the extent of deformation of the solid as a function of sliding velocity, solid elastic modulus, and bump geometry (wavelength and amplitude). For physiological values of the parameters, significant deformation occurs (i.e. bumps are 'flattened') promoting less variation in fluid thickness and decreased fluid shear stress. In addition, deformation is persistent; bumps of sufficient wavelength, once deformed, require a recovery time longer than a typical breath-to-breath interval to return near their undeformed configuration. These results suggest that in the pleural space during normal breathing, separation of pleural surfaces is promoted by the reciprocating sliding of lung and chest wall. |
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Authors:
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Andrew Gouldstone; Richard E Brown; James P Butler; Stephen H Loring |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 137 ISSN: 1569-9048 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-21 Completed Date: 2003-10-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 97-106 Citation Subset: IM |
Affiliation:
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Physiology Program, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Body Fluids
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physiology Elasticity Finite Element Analysis Lung / physiology* Models, Biological* Pleura / physiology* Respiration* Respiratory Mechanics / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL07118/HL/NHLBI NIH HHS; HL33009/HL/NHLBI NIH HHS; HL63737/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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