| Elastin metabolism is disrupted in patients after allogeneic hematopoietic stem cell transplantation (alloHSCT) for acute and chronic myeloid leukemia. | |
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MedLine Citation:
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PMID: 18971876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The potential role of elastin in patients with myeloid leukemia treated with hematopoietic stem cell transplantation (HSCT) has not been investigated so far. The objective of the study was to evaluate elastin metabolism before and at two time-points after HSCT. MATERIAL/METHODS: Forty patients (22 male and 18 female, median age: 34 years, range: 14-54) were included. The diagnoses were acute myeloid leukemia (AML, n=25) and chronic myeloid leukemia (CML, n=15). Busulfan and cyclophosphamide (4+2) were administered as conditioning. Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine and methotrexate. Twenty-three patients experienced acute GVHD and 17 developed chronic GVHD. Plasma elastase activity (EA) and plasma elastin-derived peptide concentration (EDPc) were measured. RESULTS: There were statistically significant differences in EA before HSCT (1.3 U/ml) compared with day +30 (2.9 U/ml) and day +100 (3.2 U/ml) after HSCT (p<0.001 for both). EA was also higher in patients with chronic GVHD than in those who did not develop chronic GVHD. EDPc was significantly higher on days +30 (49.3 U/ml) and +100 (57.7 U/ml) after HSCT than on day -10 before HSCT (15.5 U/ml, p<0.001 for both). EDPc was significantly higher in patients with chronic GVHD. CONCLUSIONS: EA and EDPc were increased in patients after HSCT. If the role of elastase in the pathogenesis of GVHD is confirmed, it will be possible to apply inhibitors of elastases in the treatment of this condition in the near future. |
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Authors:
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Grzegorz Helbig; Sławomira Krzemień; Tomasz Francuz; Jerzy Wojnar; Jerzy Hołowiecki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 14 ISSN: 1643-3750 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-30 Completed Date: 2008-12-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: CR584-8 Citation Subset: IM |
Affiliation:
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Department of Hematology and Bone Marrow Transplantation, Silesian Medical University, Katowice, Poland. ghelbig@tlen.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Chronic Disease Elastin / metabolism* Female Hematopoietic Stem Cell Transplantation* Humans Leukemia, Myeloid / metabolism*, surgery Male Middle Aged Pancreatic Elastase / metabolism Peptide Fragments / biosynthesis Transplantation, Homologous Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 9007-58-3/Elastin; EC 3.4.21.36/Pancreatic Elastase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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