Document Detail

Elastin-laminin receptor and abdominal aortic aneurysms. New subject to study? A review.
MedLine Citation:
PMID:  11428169     Owner:  NLM     Status:  MEDLINE    
Abdominal aortic aneurysms and their management remain a significant health problem that is likely to assume greater importance with the expansion of the elderly population. Elastin fibres degradation and extracellular matrix remodelling seems to be the basic process in aneurysm formation. Recent investigations revealed the principal role of elastin-laminin receptor in extracellular matrix remodelling in aging and atherosclerosis. The correlation between events observed in animal aneurysm models, human aneurysms and in experiments on elastin-laminin receptor properties was discussed to propose the hypothesis about the role of elastin peptides and elastin-laminin receptor in aortic aneurysm formation.
M Kunecki; A Nawrocka
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pathologie-biologie     Volume:  49     ISSN:  0369-8114     ISO Abbreviation:  Pathol. Biol.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-06-28     Completed Date:  2001-07-26     Revised Date:  2005-11-21    
Medline Journal Info:
Nlm Unique ID:  0265365     Medline TA:  Pathol Biol (Paris)     Country:  France    
Other Details:
Languages:  eng     Pagination:  333-8     Citation Subset:  IM    
Department of General and Vascular Surgery, Medical University of Lodz, Poland.
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MeSH Terms
Aortic Aneurysm, Abdominal / etiology*,  pathology
Arteriosclerosis / etiology
Elastin / metabolism
Extracellular Matrix / chemistry
Receptors, Cell Surface* / physiology
Receptors, Laminin* / physiology
Reg. No./Substance:
0/Receptors, Cell Surface; 0/Receptors, Laminin; 0/elastin-binding proteins; 9007-58-3/Elastin

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