| Elastin degradation in abdominal aortic aneurysms. | |
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MedLine Citation:
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PMID: 3649236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Histological sections through the walls of abdominal aortic aneurysms showed scarce and disrupted elastic tissue. The elastin content of the aneurysmal aortic media was only 8.1 +/- 3.2% dry defatted weight (n = 11). The elastin content of grossly normal age and anatomically matched aortic media was 35.0 +/- 3.2% dry weight (n = 4) and the elastin content of severely atherosclerotic, stenosed infrarenal aortic media was 22.0 +/- 7.2% dry weight (n = 6). There was an inverse correlation of elastin content with the elastinolytic activity of aortic media homogenates, r = -0.78. Elastase activity, measured by the hydrolysis of [3H]elastin, was highest in aneurysmal aortic homogenates, 92.1 +/- 43.7 U/mg protein (n = 18), falling to 46.9 +/- 13.3 U/mg protein (n = 13) in severely stenosed atherosclerotic aortic homogenates and 35.5 +/- 11.9 U/mg (n = 6) in grossly normal aortic homogenates. The elastinolytic activity of stenotic aorta contained leukocyte elastase as an important component. In aneurysmal homogenates leukocyte elastase was also found but the increased elastase activity resulted from a protease(s) (Mr 95,000) extracted in 2 M urea, having minimal specificity for alanyl bonds and no immunological cross-reactivity with leukocyte elastase. |
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Authors:
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J S Campa; R M Greenhalgh; J T Powell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Atherosclerosis Volume: 65 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-08-10 Completed Date: 1987-08-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 13-21 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amino Acids / analysis Aorta, Abdominal / enzymology, metabolism Aortic Aneurysm / enzymology, metabolism* Aortic Valve Stenosis / enzymology Elastin / analysis, metabolism* Female Histocytochemistry Humans Male Middle Aged Molecular Weight Pancreatic Elastase / metabolism Tissue Extracts |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Tissue Extracts; 9007-58-3/Elastin; EC 3.4.21.36/Pancreatic Elastase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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