Document Detail

Elastic tissue damage in cephalic acquired cutis laxa.
MedLine Citation:
PMID:  18095996     Owner:  NLM     Status:  MEDLINE    
Cutis laxa is a rare condition characterized by diminished elastic tissue. We report the histological changes from a 22-year-old male patient, who presented since 4 years hanging and inelastic facial skin, giving him an older appearance. The palpebral, preauricular and submandibular skin obtained after a facelift were examined. Conventional light microscopy with hematoxylin-eosin staining showed perivascular lymphocytic infiltrates and crossed-over collagen fibers. With Weigert staining, a lessening of elastic fibers with fragmentation, shortening and clumping was seen. The oxytalanic fibers in the papillary dermis were also affected, ranging from absence or reduction to flattening with clumping of the fibers, giving an irregular contour to the basal membrane zone. These findings were more intense in the palpebral skin. Transmission electronic microscopy showed reduction of the elastic fibers, a granular degeneration of the elastic tissue was found and collagen fibers were normal. Similar to light microscopy, at the ultrastructural level, the basal membrane has an irregular contour.
Hiram Larangeira de Almeida; Manfred Wolter; Márcia Vargas de Farias; Luis Antônio Suita de Castro
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  35     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-21     Completed Date:  2008-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  58-61     Citation Subset:  IM    
Department of Dermatology, Catholic University of Pelotas, Pelotas, Brazil.
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MeSH Terms
Cutis Laxa / pathology*,  surgery
Elastic Tissue / surgery,  ultrastructure*
Microscopy, Electron, Transmission
Staining and Labeling
Surgery, Plastic
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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