Document Detail

Elastic properties of the rat respiratory system related to age.
MedLine Citation:
PMID:  2967507     Owner:  NLM     Status:  MEDLINE    
The experiments were performed on male rats of the Wistar strain under urethane anaesthesia (1.3 g/kg i.p.). Changes of oesophageal and tracheal pressures were registered in a group of 30 spontaneously breathing, supine rats, of 295 +/- 13 g average body weight during lung inflations with 1-5 ml of air. In another group of 25 rats of 70 +/- 6 g average body weight (young rats) we made the measurements during inflation with volumes 0.5-2 ml. The measurements were also performed in a group of 10 paralyzed, ventilated rats with 347 +/- 24 g average body weight and inflations 1-5 ml. Compliance of the lungs (CL), chest wall (CW) and of the respiratory system (Crs) was calculated from the linear part of the pressure-volume curve during inflation. The results indicate: 1. Cw is significantly (p less than 0.001) higher in young (134.7 than in adult rats (44.1 CL (related to body weight) is not significantly different in young and adult rats. 2. Cw is significantly (p less than 0.001) higher than CL. 3. No difference was observed in CLs Cw and Crs between paralyzed and spontaneously breathing animals.
F Palecek; E Jezová
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiologia Bohemoslovaca     Volume:  37     ISSN:  0369-9463     ISO Abbreviation:  Physiol Bohemoslov     Publication Date:  1988  
Date Detail:
Created Date:  1988-07-11     Completed Date:  1988-07-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0175317     Medline TA:  Physiol Bohemoslov     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  39-48     Citation Subset:  IM    
Institute of Pathological Physiology, Faculty of Paediatrics, Charles University, Prague.
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MeSH Terms
Aging / physiology*
Esophagus / physiology
Lung Compliance*
Rats, Inbred Strains
Respiratory Physiological Phenomena*
Trachea / physiology

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