Document Detail


Elastic properties and composition of the aortic wall in old spontaneously hypertensive rats.
MedLine Citation:
PMID:  10489387     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We hypothesized that age-linked changes in the composition and elastic properties of the arterial wall occur earlier in hypertensive than in normotensive rats. We evaluated the consequences of hypertension and aging on aortic mechanics, geometry, and composition in 3-, 9-, and 15-month-old awake Wistar-Kyoto rats (WKY) (normotensive) and spontaneously hypertensive rats (SHR) (hypertensive). The elastic modulus of the thoracic aorta, calculated from aortic pulse wave velocity and geometry, was higher in young and adult SHR than in age-matched WKY, as was wall stress; however, isobaric pulse wave velocity and pulse wave velocity-pressure curves were similar. Elastic modulus, isobaric pulse wave velocity, and the slope of the pulse wave velocity-pressure curve dramatically increased in old SHR compared with age-matched WKY; there was no further elevation of blood pressure or wall thickness. Fibrosis did not develop with age in SHR, and the ratio of elastin to collagen decreased in a similar fashion with aging in both strains. In conclusion, although elastic properties of the aortic wall are not intrinsically modified in young and adult SHR in comparison to age-matched WKY, aging is associated with a dramatic stiffening of the aortic wall in old SHR but not in WKY. Changes in blood pressure, aortic wall geometry, or scleroprotein composition do not appear to explain this age-linked aortic stiffening in SHR, suggesting that other mechanisms of disorganization of the media may be involved.
Authors:
V Marque; P Kieffer; J Atkinson; I Lartaud-Idjouadiene
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  34     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-09-30     Completed Date:  1999-09-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  415-22     Citation Subset:  IM    
Affiliation:
Laboratoire de Pharmacologie Cardiovasculaire, Faculté de Pharmacie, Université Henri Poincaré-Nancy 1, Nancy, France.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Aorta, Thoracic / metabolism,  physiopathology*
Blood Pressure
Body Weight
Elasticity
Elastin / metabolism
Heart Rate
Hypertension / metabolism,  physiopathology*
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Chemical
Reg. No./Substance:
9007-58-3/Elastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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