Document Detail

Elastic pressure-volume curves of the respiratory system reveal a high tendency to lung collapse in young pigs.
MedLine Citation:
PMID:  10551973     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study pressure-volume (P/V) curves over a wide pressure and volume range in pigs. DESIGN: Dynamic and static P/V curves (P(dyn)/V and P(st)/V) and compliance of the respiratory system were studied. The effects of recruitment, positive end-expiratory pressure (PEEP) and body position were analysed. SETTING: Research animal laboratory. MATERIALS: Seven anaesthetised, paralysed and ventilated healthy pigs of 21 kg. MEASUREMENTS: P/V curves up to a pressure of about 40 cmH(2)O were recorded with a computer-controlled ventilator. P(st)/V curves were obtained with the static occlusion method and P(dyn)/V curves during an insufflation at a low, constant flow rate. RESULTS: P(dyn)/V recording showed a complex pattern. During the insufflation compliance increased, fell, increased and fell again. A 2nd P(dyn)/V recording immediately following the 1st one was displaced towards higher volumes and showed only one maximum of compliance. The difference between the two curves reflected: (1) lung collapse during a period of 5 min of ventilation at zero end-expiratory pressure (ZEEP) following a recruitment manoeuvre, (2) recruitment during the measurement of the 1st P(dyn)/V curve. These observations were similar in the supine and in the left lateral position. After ventilation at PEEP, 4 cmH(2)O, the signs of collapse and recruitment were reduced. It was confirmed that PEEP offers a partial protection against collapse. P(st)/V curves showed higher volumes and higher compliance values compared to P(dyn)/V curves. This reflects the influence of viscoelastance on P(dyn)/V curves. CONCLUSION: The study demonstrates a particularly strong tendency to lung collapse in pigs.
J M Liu; E De Robertis; S Blomquist; P L Dahm; C Svantesson; B Jonson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Intensive care medicine     Volume:  25     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-01-05     Completed Date:  2000-01-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1140-6     Citation Subset:  IM    
Department of Clinical Physiology, University Hospital, S-221 85 Lund, Sweden.
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MeSH Terms
Age Factors
Airway Resistance*
Disease Models, Animal*
Lung Compliance*
Lung Volume Measurements*
Nonlinear Dynamics
Positive-Pressure Respiration / adverse effects*,  methods*
Pulmonary Atelectasis / diagnosis*,  etiology,  physiopathology*,  prevention & control
Respiratory Insufficiency / complications,  diagnosis,  physiopathology*,  therapy*
Comment In:
Intensive Care Med. 1999 Oct;25(10):1040-3   [PMID:  10551957 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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