Document Detail

Elastic pressure-volume curves indicate derecruitment after a single deep expiration in anaesthetised and muscle-relaxed healthy man.
MedLine Citation:
PMID:  10981576     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In acute respiratory distress syndrome, lung volume is lost immediately after positive end-expiratory pressure (PEEP) is removed and is not immediately regained when PEEP is restored to its original value. The aim of this study was to investigate whether the same phenomenon also occurs in cardiopulmonary healthy individuals during anaesthesia and muscle relaxation. METHODS: In 13 anaesthetised and muscle-relaxed patients, inspiratory elastic pressure-volume (Pel-V) curves were, after lung recruitment, obtained from zero end-expiratory airway pressure (ZEEP) and from a PEEP of 5 cmH2O. The curves were aligned on a common volume axis. Differences in lung volumes and compliance (Crs) were calculated at the different airway pressures. RESULTS: At comparable pressures the ZEEP curve showed significantly lower volumes up to an airway pressure of 25 cmH2O. Maximum Crs was similar on the curves obtained from ZEEP and PEEP. However, the lower segments of the curve recorded from PEEP showed lower Crs compared to the curve recorded from ZEEP. CONCLUSION: During anaesthesia and muscle paralysis, the Pel-V relations change immediately when 5 cmH2O of PEEP is removed. This phenomenon is probably mainly caused by closure of small airways and only in a minor part, if any, by formation of atelectasis. This study indicates that under these conditions lung volume might easily be normalised by a large breath producing an airway pressure of 20 cmH2O.
S Sigurdsson; C Svantesson; A Larsson; B Jonson
Related Documents :
3902776 - Hemodynamic effects of peep applied as a ramp in normo-, hyper-, and hypovolemia.
3112106 - Cardiorespiratory changes during hcl infusion unrelated to decreases in circulating blo...
15811166 - Comparison of the effect of aminophylline and low peep vs. high peep on egf concentrati...
3893886 - Left ventricular geometry during positive end-expiratory pressure in dogs.
11574226 - Reshaping the remodelled left ventricle: a new concept.
1107946 - Circulatory reflexes in tetraplegics during artifical ventilation and general anaesthesia.
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  44     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2001-02-02     Completed Date:  2001-02-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  980-4     Citation Subset:  IM    
Department of Anaesthesia and Intensive Care, Lund University Hospital, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Air Pressure
Lung / drug effects,  physiology*
Lung Compliance / physiology
Lung Volume Measurements*
Middle Aged
Muscle Relaxants, Central / pharmacology*
Positive-Pressure Respiration*
Respiration, Artificial
Reg. No./Substance:
0/Muscle Relaxants, Central

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Helicopter emergency medical service in out-of-hospital cardiac arrest--a 10-year population-based s...
Next Document:  Intraperitoneal tonometry for detection of regional enteric ischaemia.