Document Detail

Elastic fibers in myocardial scars in rats: development teraction with other components.
MedLine Citation:
PMID:  18991085     Owner:  NLM     Status:  MEDLINE    
This work was designed to determine the course of development of elastic fibers in myocardial scars in rats and their relationship to other components of such structures. Light and electron microscopic observations were made on tissues from 24 rats, killed at sequent stages from 4 to 24 days postinjury. By both techniques, elastic fibers, shown to be forming by 4 days, had increased in size and number with maturation of the scar. At later stages they became interdigitated with the stumps of viable myocytes. We also saw that these fibers often had formed close contacts with the cell surfaces of myofibroblasts and nonvascular smooth muscle cells; a process found in some other situations but not previously in myocardial scars. This information is relevant, in particular, to the dynamics of myocardial scars and thus to the maintenance of function in the injured heart, but also to elastic fiber behavior in general. The integral role of elastic fibers in cell-matrix interactions as well as their biomechanical function is emphasized.
E Gertrude Bassett; J St John Wakefield
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Connective tissue research     Volume:  49     ISSN:  1607-8438     ISO Abbreviation:  Connect. Tissue Res.     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-10     Completed Date:  2009-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0365263     Medline TA:  Connect Tissue Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321-7     Citation Subset:  IM    
Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, Wellington, New Zealand.
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MeSH Terms
Cicatrix / pathology*
Elastic Tissue / growth & development*,  ultrastructure*
Fibroblasts / ultrastructure
Heart Injuries / pathology*
Microscopy, Electron, Transmission
Muscle Cells / ultrastructure
Myocardium / ultrastructure*
Rats, Sprague-Dawley

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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