| Elastic fiber abnormalities associated with a leaflet perforation in floppy mitral valve. | |
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MedLine Citation:
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PMID: 9697072 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The alterations observed in the elastic fibers of the perforated floppy mitral valve of a 68-year-old man are described. The patient had not history of infective endocarditis and no stigmata of Marfan syndrome or Ehlers-Danlos syndrome. Ultrastructurally, the elastic fibers in the area of the perforation showed unique, round-shaped expansion of the amorphous components, which lacked associated microfibrils. These features resembled those of the elastic fibers in animals treated with beta-aminopropionitrile, an inhibitor of lysyl oxidase. Aggregations of microfibrils without amorphous components were also observed. These abnormalities are considered to be related to the pathogenesis of the perforation in this valve. |
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Authors:
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K Tamura; Y Fukuda; V J Ferrans |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of heart valve disease Volume: 7 ISSN: 0966-8519 ISO Abbreviation: J. Heart Valve Dis. Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-10-19 Completed Date: 1998-10-19 Revised Date: 2006-05-04 |
Medline Journal Info:
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Nlm Unique ID: 9312096 Medline TA: J Heart Valve Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 460-6 Citation Subset: IM |
Affiliation:
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Department of Pathology, Nippon Medical School, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Chordae Tendineae / injuries, ultrastructure Elastic Tissue / ultrastructure Heart Valve Prosthesis Implantation Humans Male Microscopy, Electron Mitral Valve / ultrastructure* Mitral Valve Prolapse / complications, pathology*, surgery Rupture, Spontaneous |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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