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Elastic characterization of the gerbil pars flaccida from in situ inflation experiments.
MedLine Citation:
PMID:  21069415     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In hearing science, finite element modelling is used commonly to study the mechanical behaviour of the middle ear. Correct quantitative elasticity parameters are an important input in these models. However, up till now, no large deformation elastic characterization of the pars flaccida, a small part of the tympanic membrane, has been carried out. In this paper, an elastic characterization of the gerbil pars flaccida is presented. The gerbil is used frequently as animal model in middle ear mechanics research. Characterization was done via inverse analysis of in situ static pressure inflation experiments. As a first approach, the pars flaccida was modelled as a linear homogeneous isotropic elastic membrane, which resulted in an average Young's modulus of [Formula: see text]. It was found that linear elastic modelling cannot describe inflation stagnation at high pressures. Therefore, in a second approach, the Veronda-Westmann hyperelastic model was introduced. This was able to describe curve stagnation, the mean parameters that were found are [Formula: see text] and [Formula: see text]. Finally, in situ strain was considered in the finite element models which resulted in a better description of the behaviour for small pressures. Incorporating this, the optimal Veronda-Westmann parameters are [Formula: see text], [Formula: see text] for a radial in situ strain of [Formula: see text]. In conclusion, this paper shows that a linear elastic material is not appropriate to describe pars flaccida's behaviour in the quasi-static pressure regime, that the currently used membrane stiffness estimates do not hold for large deformations and that incorporating an in situ strain in the models is necessary for a good description for small static pressures.
Authors:
Jef Aernouts; Joris J J Dirckx
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Publication Detail:
Type:  Journal Article     Date:  2010-11-11
Journal Detail:
Title:  Biomechanics and modeling in mechanobiology     Volume:  10     ISSN:  1617-7940     ISO Abbreviation:  Biomech Model Mechanobiol     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135325     Medline TA:  Biomech Model Mechanobiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  727-41     Citation Subset:  IM; S    
Affiliation:
Laboratory of Biomedical Physics, University of Antwerp, Groenenborgerlaan 171, 2020, Antwerp, Belgium, jef.aernouts@ua.ac.be.
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