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Elastic characteristics of microspherical embolic agents used for vascular interventional radiology.
MedLine Citation:
PMID:  20696414     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Embolic agents are used in vascular interventional radiology to occlude arteries under pathological conditions. The present study was performed to investigate the material properties of two microspherical embolic agents (MSEAs), tris-acryl gelatin microspheres (TGMS) and superabsorbent polymer microsphere (SAP-MS), using a loading-unloading compression test. The results demonstrated that for both TGMS and SAP-MS, the stress-strain relationship appeared to be linear up to 25% deformation. Therefore, one can reasonably treat TGMS and SAP-MS as linearly elastic materials for this range of deformation and apply the Hertz contact theory for analysis of the Young's modulus. The Young's moduli of TGMS and the SAP-MS obtained by applying Hertz theory under the assumption of a Poisson's ratio of 0.5 were 19.33 +/- 4.97 kPa and 9.64 +/- 2.46 kPa, respectively (mean +/- SD, P<0.001, Mann-Whitney U-test), indicating that TGMS showed higher stiffness than SAP-MS. The effects of a difference in these mechanical characteristics of embolic agents on the performance of interventional radiology were discussed from a viewpoint of their flowing behavior and clinical aspects.
Authors:
Kuniyuki Hidaka; Masanori Nakamura; Keigo Osuga; Hiroshi Miyazaki; Shigeo Wada
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Publication Detail:
Type:  Journal Article     Date:  2010-05-11
Journal Detail:
Title:  Journal of the mechanical behavior of biomedical materials     Volume:  3     ISSN:  1878-0180     ISO Abbreviation:  J Mech Behav Biomed Mater     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101322406     Medline TA:  J Mech Behav Biomed Mater     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  497-503     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka, Japan. hidaka@hp-rad.med.osaka-u.ac.jp
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